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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E2
All Species:
18.18
Human Site:
T108
Identified Species:
28.57
UniProt:
O60573
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60573
NP_004837.1
245
28362
T108
M
V
R
P
G
D
L
T
G
H
S
D
F
H
L
Chimpanzee
Pan troglodytes
XP_516153
236
27201
T108
M
V
R
P
G
D
L
T
G
H
S
D
F
H
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545602
245
28254
T108
M
V
R
P
G
D
L
T
G
H
S
D
F
H
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMB3
245
28244
T108
M
V
R
P
G
D
L
T
G
H
S
D
F
H
L
Rat
Rattus norvegicus
P63074
217
25035
W102
K
D
G
I
E
P
M
W
E
D
E
K
N
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232426
247
28450
T108
M
V
R
P
G
D
L
T
G
H
S
D
F
H
L
Frog
Xenopus laevis
P48597
213
24616
Q117
L
I
T
L
N
K
Q
Q
R
R
N
D
L
D
R
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
Q119
L
I
T
L
S
K
Q
Q
R
R
A
D
L
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
K130
I
K
P
P
S
E
I
K
L
G
S
D
Y
S
L
Honey Bee
Apis mellifera
XP_623570
273
31794
W116
K
V
G
I
K
P
M
W
E
D
E
A
N
Q
K
Nematode Worm
Caenorhab. elegans
Q22888
212
24566
D102
G
V
K
P
V
W
E
D
P
A
N
C
K
G
G
Sea Urchin
Strong. purpuratus
NP_001077102
227
26298
H106
L
T
S
S
S
D
Y
H
L
F
K
H
G
I
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
F103
V
G
A
D
F
H
C
F
K
N
K
I
E
P
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
W111
K
D
G
I
R
P
L
W
E
D
G
A
N
C
N
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
E107
V
R
P
E
W
E
D
E
A
N
A
K
G
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.4
N.A.
95.9
N.A.
98.3
28.9
N.A.
N.A.
87.8
29.3
29.3
N.A.
28.9
55.6
43.2
61.6
Protein Similarity:
100
92.2
N.A.
97.1
N.A.
99.5
49.3
N.A.
N.A.
91.5
50.6
49.3
N.A.
50.1
67.7
57.9
71.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
N.A.
100
6.6
6.6
N.A.
26.6
6.6
13.3
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
N.A.
100
26.6
26.6
N.A.
53.3
13.3
26.6
13.3
Percent
Protein Identity:
N.A.
32.6
N.A.
41.6
28.1
N.A.
Protein Similarity:
N.A.
53.8
N.A.
58.7
48.1
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
0
7
7
14
14
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
7
0
7
0
% C
% Asp:
0
14
0
7
0
40
7
7
0
20
0
54
0
14
0
% D
% Glu:
0
0
0
7
7
14
7
7
20
0
14
0
7
0
0
% E
% Phe:
0
0
0
0
7
0
0
7
0
7
0
0
34
0
0
% F
% Gly:
7
7
20
0
34
0
0
0
34
7
7
0
14
14
7
% G
% His:
0
0
0
0
0
7
0
7
0
34
0
7
0
34
0
% H
% Ile:
7
14
0
20
0
0
7
0
0
0
0
7
0
7
0
% I
% Lys:
20
7
7
0
7
14
0
7
7
0
14
14
7
7
27
% K
% Leu:
20
0
0
14
0
0
40
0
14
0
0
0
14
0
40
% L
% Met:
34
0
0
0
0
0
14
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
14
14
0
20
0
7
% N
% Pro:
0
0
14
47
0
20
0
0
7
0
0
0
0
7
0
% P
% Gln:
0
0
0
0
0
0
14
14
0
0
0
0
0
7
0
% Q
% Arg:
0
7
34
0
7
0
0
0
14
14
0
0
0
0
20
% R
% Ser:
0
0
7
7
20
0
0
0
0
0
40
0
0
7
0
% S
% Thr:
0
7
14
0
0
0
0
34
0
0
0
0
0
0
0
% T
% Val:
14
47
0
0
7
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
7
7
0
20
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _