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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E2
All Species:
21.52
Human Site:
T87
Identified Species:
33.81
UniProt:
O60573
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60573
NP_004837.1
245
28362
T87
Q
N
I
K
Q
I
G
T
F
A
S
V
E
Q
F
Chimpanzee
Pan troglodytes
XP_516153
236
27201
T87
Q
N
I
K
Q
I
G
T
F
A
S
V
E
Q
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545602
245
28254
T87
Q
N
I
K
Q
I
G
T
F
A
S
V
E
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMB3
245
28244
T87
Q
N
I
K
Q
I
G
T
F
A
S
V
E
Q
F
Rat
Rattus norvegicus
P63074
217
25035
L81
A
L
Y
N
H
I
Q
L
S
S
N
L
M
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232426
247
28450
T87
Q
N
I
K
Q
I
G
T
F
A
S
V
E
Q
F
Frog
Xenopus laevis
P48597
213
24616
P96
L
F
K
D
G
I
E
P
M
W
E
D
E
K
N
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
P98
L
F
K
D
G
I
E
P
M
W
E
D
E
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
S109
D
M
Q
N
E
I
T
S
F
D
T
V
E
D
F
Honey Bee
Apis mellifera
XP_623570
273
31794
R95
S
L
Y
S
H
L
V
R
P
S
E
L
T
T
S
Nematode Worm
Caenorhab. elegans
Q22888
212
24566
T81
M
V
H
F
K
R
P
T
E
M
C
D
K
A
D
Sea Urchin
Strong. purpuratus
NP_001077102
227
26298
Q85
G
S
F
A
S
V
E
Q
F
W
T
L
Y
S
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
W82
F
S
T
V
E
E
F
W
G
L
Y
N
N
I
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
R90
A
C
Y
C
H
L
A
R
S
S
L
L
P
S
P
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
E86
Q
N
I
P
E
P
H
E
L
P
L
K
S
D
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.4
N.A.
95.9
N.A.
98.3
28.9
N.A.
N.A.
87.8
29.3
29.3
N.A.
28.9
55.6
43.2
61.6
Protein Similarity:
100
92.2
N.A.
97.1
N.A.
99.5
49.3
N.A.
N.A.
91.5
50.6
49.3
N.A.
50.1
67.7
57.9
71.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
N.A.
100
13.3
13.3
N.A.
33.3
0
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
N.A.
100
20
20
N.A.
53.3
20
20
33.3
Percent
Protein Identity:
N.A.
32.6
N.A.
41.6
28.1
N.A.
Protein Similarity:
N.A.
53.8
N.A.
58.7
48.1
N.A.
P-Site Identity:
N.A.
0
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
7
0
0
7
0
0
34
0
0
0
7
0
% A
% Cys:
0
7
0
7
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
0
14
0
0
0
0
0
7
0
20
0
14
7
% D
% Glu:
0
0
0
0
20
7
20
7
7
0
20
0
54
0
0
% E
% Phe:
7
14
7
7
0
0
7
0
47
0
0
0
0
0
40
% F
% Gly:
7
0
0
0
14
0
34
0
7
0
0
0
0
0
7
% G
% His:
0
0
7
0
20
0
7
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
40
0
0
60
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
0
14
34
7
0
0
0
0
0
0
7
7
7
0
% K
% Leu:
14
14
0
0
0
14
0
7
7
7
14
27
0
0
0
% L
% Met:
7
7
0
0
0
0
0
0
14
7
0
0
7
0
0
% M
% Asn:
0
40
0
14
0
0
0
0
0
0
7
7
7
0
20
% N
% Pro:
0
0
0
7
0
7
7
14
7
7
0
0
7
7
7
% P
% Gln:
40
0
7
0
34
0
7
7
0
0
0
0
0
34
0
% Q
% Arg:
0
0
0
0
0
7
0
14
0
0
0
0
0
7
0
% R
% Ser:
7
14
0
7
7
0
0
7
14
20
34
0
7
14
7
% S
% Thr:
0
0
7
0
0
0
7
40
0
0
14
0
7
7
0
% T
% Val:
0
7
0
7
0
7
7
0
0
0
0
40
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
20
0
0
0
0
0
% W
% Tyr:
0
0
20
0
0
0
0
0
0
0
7
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _