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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICMT All Species: 26.67
Human Site: S120 Identified Species: 41.9
UniProt: O60725 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60725 NP_036537.1 284 31938 S120 V N N P K S L S L D S F L L N
Chimpanzee Pan troglodytes XP_525166 284 31950 S120 V N N P K S L S L D S F L L N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546748 284 31977 S120 V N N P K S L S L D S F L L N
Cat Felis silvestris
Mouse Mus musculus Q9EQK7 283 31771 S119 V N N P K S L S L D S F L L N
Rat Rattus norvegicus Q9WVM4 232 26642 H76 L D S F L L N H S L E Y T V A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507547 219 25211 H63 L D S F L L N H S V E Y S V A
Chicken Gallus gallus NP_001006298 297 33156 S133 I N N P R S L S L D S F L L N
Frog Xenopus laevis O12947 288 32413 S124 M N N P R S L S I D S F L L N
Zebra Danio Brachydanio rerio Q6ZM63 285 32608 P118 I E L Y T H L P V M K Q L V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648623 299 34085 S136 F A N P R T L S L D S F M L N
Honey Bee Apis mellifera XP_001122123 232 26974 H76 I D S F I L N H S I A Y G V A
Nematode Worm Caenorhab. elegans NP_491473 295 33416 G133 L T N R R T L G P D S F L L K
Sea Urchin Strong. purpuratus XP_001201998 217 24994 L61 L S L D S Y L L N H S I A Y H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93W54 197 22747 V40 A I H G A S K V T L S S L L I
Baker's Yeast Sacchar. cerevisiae P32584 239 27869 N83 H S E S F L L N N G K S Y M A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 97.1 N.A. 94.3 76.4 N.A. 68.6 74.7 71.5 20 N.A. 48.1 43.6 35.2 45.7
Protein Similarity: 100 99.6 N.A. 98.5 N.A. 96.4 78.5 N.A. 72.5 82.1 81.9 37.8 N.A. 65.8 59.8 53.5 58.1
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 0 86.6 80 13.3 N.A. 66.6 0 46.6 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 33.3 N.A. 33.3 100 100 33.3 N.A. 86.6 40 66.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. 32.7 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. 47.5 47.5 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 0 7 0 0 0 0 0 7 0 7 0 27 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 20 0 7 0 0 0 0 0 54 0 0 0 0 0 % D
% Glu: 0 7 7 0 0 0 0 0 0 0 14 0 0 0 7 % E
% Phe: 7 0 0 20 7 0 0 0 0 0 0 54 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 7 0 7 0 0 7 0 0 % G
% His: 7 0 7 0 0 7 0 20 0 7 0 0 0 0 7 % H
% Ile: 20 7 0 0 7 0 0 0 7 7 0 7 0 0 7 % I
% Lys: 0 0 0 0 27 0 7 0 0 0 14 0 0 0 7 % K
% Leu: 27 0 14 0 14 27 74 7 40 14 0 0 60 60 0 % L
% Met: 7 0 0 0 0 0 0 0 0 7 0 0 7 7 0 % M
% Asn: 0 40 54 0 0 0 20 7 14 0 0 0 0 0 47 % N
% Pro: 0 0 0 47 0 0 0 7 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 0 0 0 7 27 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 14 20 7 7 47 0 47 20 0 67 14 7 0 0 % S
% Thr: 0 7 0 0 7 14 0 0 7 0 0 0 7 0 0 % T
% Val: 27 0 0 0 0 0 0 7 7 7 0 0 0 27 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 7 0 0 0 0 0 20 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _