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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICMT All Species: 26.36
Human Site: T111 Identified Species: 41.43
UniProt: O60725 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60725 NP_036537.1 284 31938 T111 H Y S E Y L V T A V N N P K S
Chimpanzee Pan troglodytes XP_525166 284 31950 T111 H Y S E Y L V T A V N N P K S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546748 284 31977 T111 H Y S E Y L V T A V N N P K S
Cat Felis silvestris
Mouse Mus musculus Q9EQK7 283 31771 T110 H Y S E Y L V T A V N N P K S
Rat Rattus norvegicus Q9WVM4 232 26642 L67 T V N N P K S L S L D S F L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507547 219 25211 L54 A V N N P K S L S L D S F L L
Chicken Gallus gallus NP_001006298 297 33156 T124 H Y S E Y L V T A I N N P R S
Frog Xenopus laevis O12947 288 32413 T115 H Y S E Y L V T A M N N P R S
Zebra Danio Brachydanio rerio Q6ZM63 285 32608 G109 Y I L F D C P G Q I E L Y T H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648623 299 34085 I127 H Y S E F L V I A F A N P R T
Honey Bee Apis mellifera XP_001122123 232 26974 L67 A W I N P S S L S I D S F I L
Nematode Worm Caenorhab. elegans NP_491473 295 33416 T124 H F S E F V F T A L T N R R T
Sea Urchin Strong. purpuratus XP_001201998 217 24994 E52 S T C I Y N Y E S L S L D S Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93W54 197 22747 A31 H T S E Y I L A I A I H G A S
Baker's Yeast Sacchar. cerevisiae P32584 239 27869 K74 T A K Y N P L K V H S E S F L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 97.1 N.A. 94.3 76.4 N.A. 68.6 74.7 71.5 20 N.A. 48.1 43.6 35.2 45.7
Protein Similarity: 100 99.6 N.A. 98.5 N.A. 96.4 78.5 N.A. 72.5 82.1 81.9 37.8 N.A. 65.8 59.8 53.5 58.1
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 0 86.6 86.6 0 N.A. 60 0 40 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 33.3 N.A. 33.3 100 100 13.3 N.A. 80 33.3 80 26.6
Percent
Protein Identity: N.A. N.A. N.A. 32.7 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. 47.5 47.5 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 0 0 0 0 0 7 54 7 7 0 0 7 0 % A
% Cys: 0 0 7 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 0 0 0 0 20 0 7 0 0 % D
% Glu: 0 0 0 60 0 0 0 7 0 0 7 7 0 0 0 % E
% Phe: 0 7 0 7 14 0 7 0 0 7 0 0 20 7 0 % F
% Gly: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 0 % G
% His: 60 0 0 0 0 0 0 0 0 7 0 7 0 0 7 % H
% Ile: 0 7 7 7 0 7 0 7 7 20 7 0 0 7 0 % I
% Lys: 0 0 7 0 0 14 0 7 0 0 0 0 0 27 0 % K
% Leu: 0 0 7 0 0 47 14 20 0 27 0 14 0 14 27 % L
% Met: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 14 20 7 7 0 0 0 0 40 54 0 0 0 % N
% Pro: 0 0 0 0 20 7 7 0 0 0 0 0 47 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 7 27 0 % R
% Ser: 7 0 60 0 0 7 20 0 27 0 14 20 7 7 47 % S
% Thr: 14 14 0 0 0 0 0 47 0 0 7 0 0 7 14 % T
% Val: 0 14 0 0 0 7 47 0 7 27 0 0 0 0 0 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 47 0 7 54 0 7 0 0 0 0 0 7 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _