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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICMT All Species: 30.61
Human Site: T272 Identified Species: 48.1
UniProt: O60725 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60725 NP_036537.1 284 31938 T272 E Y K K R V P T G L P F I K G
Chimpanzee Pan troglodytes XP_525166 284 31950 T272 E Y K K R V P T G L P F I K G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546748 284 31977 T272 E Y K K R V P T G L P F I K G
Cat Felis silvestris
Mouse Mus musculus Q9EQK7 283 31771 T271 D Y K K R V P T G L P F I K G
Rat Rattus norvegicus Q9WVM4 232 26642 I225 V P T G L P F I K G V K V G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507547 219 25211 I212 V P T G L P F I S G V K V E L
Chicken Gallus gallus NP_001006298 297 33156 S285 E Y K R K V P S G L P F I K G
Frog Xenopus laevis O12947 288 32413 T276 E Y K K K V P T G L P F I K G
Zebra Danio Brachydanio rerio Q6ZM63 285 32608 E269 E P K E V D E E P S N S N F D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648623 299 34085 T288 R Y Q K R V P T G L P F I R G
Honey Bee Apis mellifera XP_001122123 232 26974 I225 V S T G L P F I S G Y K L D L
Nematode Worm Caenorhab. elegans NP_491473 295 33416 S284 E Y Q R K T W S G V P F A R G
Sea Urchin Strong. purpuratus XP_001201998 217 24994 P210 K R V G T M L P F I Q G Y K L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93W54 197 22747 P190 V E Y A Q R V P S G V P F V N
Baker's Yeast Sacchar. cerevisiae P32584 239 27869 V232 Y I E Y K N K V G V G I P F I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 97.1 N.A. 94.3 76.4 N.A. 68.6 74.7 71.5 20 N.A. 48.1 43.6 35.2 45.7
Protein Similarity: 100 99.6 N.A. 98.5 N.A. 96.4 78.5 N.A. 72.5 82.1 81.9 37.8 N.A. 65.8 59.8 53.5 58.1
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 0 N.A. 0 80 93.3 13.3 N.A. 80 0 40 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 6.6 N.A. 13.3 100 100 20 N.A. 93.3 6.6 80 26.6
Percent
Protein Identity: N.A. N.A. N.A. 32.7 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. 47.5 47.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 7 0 0 0 0 0 0 0 7 7 % D
% Glu: 47 7 7 7 0 0 7 7 0 0 0 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 20 0 7 0 0 54 7 14 0 % F
% Gly: 0 0 0 27 0 0 0 0 60 27 7 7 0 7 54 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 0 0 20 0 7 0 7 47 0 7 % I
% Lys: 7 0 47 40 27 0 7 0 7 0 0 20 0 47 0 % K
% Leu: 0 0 0 0 20 0 7 0 0 47 0 0 7 0 27 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 7 0 0 0 0 7 0 7 0 7 % N
% Pro: 0 20 0 0 0 20 47 14 7 0 54 7 7 0 0 % P
% Gln: 0 0 14 0 7 0 0 0 0 0 7 0 0 0 0 % Q
% Arg: 7 7 0 14 34 7 0 0 0 0 0 0 0 14 0 % R
% Ser: 0 7 0 0 0 0 0 14 20 7 0 7 0 0 0 % S
% Thr: 0 0 20 0 7 7 0 40 0 0 0 0 0 0 0 % T
% Val: 27 0 7 0 7 47 7 7 0 14 20 0 14 7 0 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % W
% Tyr: 7 54 7 7 0 0 0 0 0 0 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _