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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICMT All Species: 23.94
Human Site: Y64 Identified Species: 37.62
UniProt: O60725 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60725 NP_036537.1 284 31938 Y64 L L Y R P P R Y Q I A I R A C
Chimpanzee Pan troglodytes XP_525166 284 31950 Y64 L L Y R P P R Y Q I A I R A C
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546748 284 31977 Y64 L L Y R P P R Y Q I A I R A C
Cat Felis silvestris
Mouse Mus musculus Q9EQK7 283 31771 Y63 L L Y R P P R Y Q I A I R A C
Rat Rattus norvegicus Q9WVM4 232 26642 G22 A I R A C F L G F V F G C G V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507547 219 25211 G9 A I R A C F L G F V F G C G L
Chicken Gallus gallus NP_001006298 297 33156 Y77 L L Y P R P L Y K I A I R A G
Frog Xenopus laevis O12947 288 32413 Y68 L L Y K A Q L Y Q V A I R A S
Zebra Danio Brachydanio rerio Q6ZM63 285 32608 M64 L I Q V D D V M E D D S L R F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648623 299 34085 Y79 F V L R N H D Y Q V A I R A S
Honey Bee Apis mellifera XP_001122123 232 26974 Y22 V R A V F L G Y G F G I G I I
Nematode Worm Caenorhab. elegans NP_491473 295 33416 M79 F I N N Q I L M P A A F L G C
Sea Urchin Strong. purpuratus XP_001201998 217 24994
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93W54 197 22747
Baker's Yeast Sacchar. cerevisiae P32584 239 27869 I29 E V T M T S Y I L G I L L G I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 97.1 N.A. 94.3 76.4 N.A. 68.6 74.7 71.5 20 N.A. 48.1 43.6 35.2 45.7
Protein Similarity: 100 99.6 N.A. 98.5 N.A. 96.4 78.5 N.A. 72.5 82.1 81.9 37.8 N.A. 65.8 59.8 53.5 58.1
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 0 66.6 60 6.6 N.A. 46.6 13.3 13.3 0
P-Site Similarity: 100 100 N.A. 100 N.A. 100 13.3 N.A. 13.3 73.3 73.3 20 N.A. 60 20 20 0
Percent
Protein Identity: N.A. N.A. N.A. 32.7 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. 47.5 47.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 7 14 7 0 0 0 0 7 54 0 0 47 0 % A
% Cys: 0 0 0 0 14 0 0 0 0 0 0 0 14 0 34 % C
% Asp: 0 0 0 0 7 7 7 0 0 7 7 0 0 0 0 % D
% Glu: 7 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % E
% Phe: 14 0 0 0 7 14 0 0 14 7 14 7 0 0 7 % F
% Gly: 0 0 0 0 0 0 7 14 7 7 7 14 7 27 7 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 27 0 0 0 7 0 7 0 34 7 54 0 7 14 % I
% Lys: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % K
% Leu: 47 40 7 0 0 7 34 0 7 0 0 7 20 0 7 % L
% Met: 0 0 0 7 0 0 0 14 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 7 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 27 34 0 0 7 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 7 7 0 0 40 0 0 0 0 0 0 % Q
% Arg: 0 7 14 34 7 0 27 0 0 0 0 0 47 7 0 % R
% Ser: 0 0 0 0 0 7 0 0 0 0 0 7 0 0 14 % S
% Thr: 0 0 7 0 7 0 0 0 0 0 0 0 0 0 0 % T
% Val: 7 14 0 14 0 0 7 0 0 27 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 40 0 0 0 7 54 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _