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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB2
All Species:
18.48
Human Site:
Y14
Identified Species:
45.19
UniProt:
O60825
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60825
NP_001018063.1
505
58477
Y14
S
E
Q
N
N
N
S
Y
E
T
K
T
P
N
L
Chimpanzee
Pan troglodytes
XP_001165887
467
54154
Y14
S
E
Q
N
N
N
S
Y
E
T
K
T
P
N
L
Rhesus Macaque
Macaca mulatta
XP_001082732
471
54341
Y14
S
E
Q
N
N
N
S
Y
E
T
K
T
P
N
L
Dog
Lupus familis
XP_537134
518
59712
Y16
S
E
Q
N
N
N
S
Y
E
T
K
T
S
N
L
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
Y17
E
D
S
C
N
S
S
Y
K
P
H
A
S
N
L
Rat
Rattus norvegicus
Q9JJH5
557
64138
Y17
E
D
S
S
S
S
S
Y
K
P
H
A
S
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
C77
L
A
L
R
T
V
L
C
K
I
Y
I
S
L
D
Chicken
Gallus gallus
Q91348
470
54386
K16
L
T
Q
N
P
L
Q
K
V
W
V
P
L
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
K11
P
P
G
L
E
T
T
K
R
K
V
A
H
S
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.8
90.6
94.7
N.A.
89.9
84.1
N.A.
62
60.9
N.A.
N.A.
N.A.
N.A.
N.A.
44.5
N.A.
Protein Similarity:
100
91.6
91.4
95.9
N.A.
94
87.9
N.A.
72.8
75.6
N.A.
N.A.
N.A.
N.A.
N.A.
62.3
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
33.3
26.6
N.A.
0
20
N.A.
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
53.3
60
N.A.
6.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
0
0
30
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
20
0
0
0
0
0
0
0
0
0
0
0
0
20
% D
% Glu:
20
40
0
0
10
0
0
0
40
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
20
0
10
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
20
30
10
40
0
0
0
0
% K
% Leu:
20
0
10
10
0
10
10
0
0
0
0
0
10
10
70
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
50
50
40
0
0
0
0
0
0
0
60
0
% N
% Pro:
10
10
0
0
10
0
0
0
0
20
0
10
30
0
0
% P
% Gln:
0
0
50
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% R
% Ser:
40
0
20
10
10
20
60
0
0
0
0
0
40
20
0
% S
% Thr:
0
10
0
0
10
10
10
0
0
40
0
40
0
0
0
% T
% Val:
0
0
0
0
0
10
0
0
10
0
20
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
60
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _