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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB2
All Species:
22.42
Human Site:
Y33
Identified Species:
54.81
UniProt:
O60825
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60825
NP_001018063.1
505
58477
Y33
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
L
Chimpanzee
Pan troglodytes
XP_001165887
467
54154
Y33
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
L
Rhesus Macaque
Macaca mulatta
XP_001082732
471
54341
Y33
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
L
Dog
Lupus familis
XP_537134
518
59712
Y35
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
L
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
Y36
K
T
C
S
W
A
S
Y
M
T
N
S
P
T
L
Rat
Rattus norvegicus
Q9JJH5
557
64138
Y36
K
K
C
S
W
A
S
Y
M
T
N
S
P
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
Q96
L
P
G
T
C
G
P
Q
L
T
N
S
P
T
V
Chicken
Gallus gallus
Q91348
470
54386
Q35
R
R
G
S
T
V
P
Q
F
T
N
C
P
T
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
N30
S
D
Q
V
R
V
P
N
V
I
V
M
V
G
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
K26
V
G
L
P
A
R
G
K
S
F
I
S
Q
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.8
90.6
94.7
N.A.
89.9
84.1
N.A.
62
60.9
N.A.
N.A.
N.A.
N.A.
N.A.
44.5
N.A.
Protein Similarity:
100
91.6
91.4
95.9
N.A.
94
87.9
N.A.
72.8
75.6
N.A.
N.A.
N.A.
N.A.
N.A.
62.3
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
33.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
53.3
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
60
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
60
0
10
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% F
% Gly:
0
10
20
0
0
10
10
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
10
% I
% Lys:
60
50
0
0
0
0
0
10
0
0
0
0
0
10
0
% K
% Leu:
10
0
10
0
0
0
0
0
10
0
0
0
0
0
70
% L
% Met:
0
0
0
0
0
0
0
0
60
0
0
10
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
80
0
0
0
0
% N
% Pro:
0
10
0
10
0
0
30
0
0
0
0
0
80
0
0
% P
% Gln:
0
0
10
0
0
0
0
20
0
0
0
0
10
0
0
% Q
% Arg:
10
10
0
0
10
10
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
0
70
0
0
60
0
10
0
0
80
0
0
0
% S
% Thr:
0
10
0
10
10
0
0
0
0
80
0
0
0
80
0
% T
% Val:
10
0
0
10
0
20
0
0
10
0
10
0
10
0
10
% V
% Trp:
0
0
0
0
60
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
60
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _