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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFKFB2 All Species: 19.09
Human Site: Y337 Identified Species: 46.67
UniProt: O60825 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60825 NP_001018063.1 505 58477 Y337 G V C E E M T Y A E I E K R Y
Chimpanzee Pan troglodytes XP_001165887 467 54154 T310 Q L K R T I Q T A E S L G V P
Rhesus Macaque Macaca mulatta XP_001082732 471 54341 V316 Q T A E S L G V P Y E Q W K I
Dog Lupus familis XP_537134 518 59712 Y339 G V C E E M T Y A Q I E K Q Y
Cat Felis silvestris
Mouse Mus musculus P70265 519 59907 Y340 G V C E E M T Y S E I E Q R Y
Rat Rattus norvegicus Q9JJH5 557 64138 Y340 G V C E E M T Y S E I E Q R Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516067 579 65588 Y400 G V C E E M T Y D E I K E K Y
Chicken Gallus gallus Q91348 470 54386 A312 M K R T I E T A E A L G V P Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q21122 457 52072 A303 W C S Q K V R A A Q T A Q H L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32604 452 52576 K298 P Y K K L Q W K A L D E L D A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.8 90.6 94.7 N.A. 89.9 84.1 N.A. 62 60.9 N.A. N.A. N.A. N.A. N.A. 44.5 N.A.
Protein Similarity: 100 91.6 91.4 95.9 N.A. 94 87.9 N.A. 72.8 75.6 N.A. N.A. N.A. N.A. N.A. 62.3 N.A.
P-Site Identity: 100 13.3 6.6 86.6 N.A. 86.6 86.6 N.A. 73.3 13.3 N.A. N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 26.6 26.6 100 N.A. 100 100 N.A. 93.3 20 N.A. N.A. N.A. N.A. N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 42.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 63.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 20 50 10 0 10 0 0 10 % A
% Cys: 0 10 50 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 10 0 10 0 0 10 0 % D
% Glu: 0 0 0 60 50 10 0 0 10 50 10 50 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 50 0 0 0 0 0 10 0 0 0 0 10 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 10 10 0 0 0 0 50 0 0 0 10 % I
% Lys: 0 10 20 10 10 0 0 10 0 0 0 10 20 20 0 % K
% Leu: 0 10 0 0 10 10 0 0 0 10 10 10 10 0 10 % L
% Met: 10 0 0 0 0 50 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 0 0 0 0 0 0 10 0 0 0 0 10 10 % P
% Gln: 20 0 0 10 0 10 10 0 0 20 0 10 30 10 0 % Q
% Arg: 0 0 10 10 0 0 10 0 0 0 0 0 0 30 0 % R
% Ser: 0 0 10 0 10 0 0 0 20 0 10 0 0 0 0 % S
% Thr: 0 10 0 10 10 0 60 10 0 0 10 0 0 0 0 % T
% Val: 0 50 0 0 0 10 0 10 0 0 0 0 10 10 0 % V
% Trp: 10 0 0 0 0 0 10 0 0 0 0 0 10 0 0 % W
% Tyr: 0 10 0 0 0 0 0 50 0 10 0 0 0 0 60 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _