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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB2
All Species:
18.48
Human Site:
Y358
Identified Species:
45.19
UniProt:
O60825
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60825
NP_001018063.1
505
58477
Y358
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
E
S
Chimpanzee
Pan troglodytes
XP_001165887
467
54154
V331
L
N
E
I
D
A
G
V
C
E
E
M
T
Y
A
Rhesus Macaque
Macaca mulatta
XP_001082732
471
54341
Y337
G
V
C
E
E
M
T
Y
A
E
I
E
K
R
Y
Dog
Lupus familis
XP_537134
518
59712
Y360
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
E
S
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
Y361
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
E
S
Rat
Rattus norvegicus
Q9JJH5
557
64138
Y361
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
Y421
R
D
Q
D
K
Y
Y
Y
R
Y
P
S
G
E
S
Chicken
Gallus gallus
Q91348
470
54386
C333
N
E
I
D
A
G
V
C
E
E
M
T
Y
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
E324
E
Y
W
K
A
L
D
E
L
D
A
G
I
C
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
E319
T
Y
E
E
I
E
K
E
Y
P
E
D
F
K
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.8
90.6
94.7
N.A.
89.9
84.1
N.A.
62
60.9
N.A.
N.A.
N.A.
N.A.
N.A.
44.5
N.A.
Protein Similarity:
100
91.6
91.4
95.9
N.A.
94
87.9
N.A.
72.8
75.6
N.A.
N.A.
N.A.
N.A.
N.A.
62.3
N.A.
P-Site Identity:
100
0
13.3
100
N.A.
100
100
N.A.
80
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
20
20
100
N.A.
100
100
N.A.
86.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
20
10
0
0
10
0
10
0
0
0
20
% A
% Cys:
0
0
10
0
0
0
0
10
10
0
0
0
0
10
0
% C
% Asp:
0
50
0
20
10
0
10
0
0
10
0
10
0
0
0
% D
% Glu:
10
10
20
60
10
10
0
20
10
30
20
10
0
60
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
10
0
0
0
0
10
10
0
0
0
0
50
50
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
10
10
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
0
0
0
10
50
0
10
0
0
0
0
0
10
10
0
% K
% Leu:
10
0
0
0
0
10
40
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
10
10
0
0
0
% M
% Asn:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
50
0
0
0
0
% P
% Gln:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
50
0
0
0
0
0
0
0
50
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
50
% S
% Thr:
10
0
0
0
0
0
10
0
0
0
0
10
10
0
0
% T
% Val:
0
10
0
0
0
0
10
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
20
0
0
0
50
10
60
10
50
0
0
10
10
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _