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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF5B All Species: 16.36
Human Site: S121 Identified Species: 25.71
UniProt: O60841 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60841 NP_056988.3 1220 138827 S121 E E L E D K D S K S K K T A K
Chimpanzee Pan troglodytes XP_001159716 1220 138677 S121 E E L E D K D S K S K K T A K
Rhesus Macaque Macaca mulatta XP_001103720 1526 171398 S426 E E L E D K D S K S K K T A K
Dog Lupus familis XP_851262 1220 138726 S122 E E W E D K D S K S K K T A K
Cat Felis silvestris
Mouse Mus musculus Q05D44 1216 137597 D121 S E E L E D K D S K S K K T A
Rat Rattus norvegicus B2GUV7 1216 137668 D121 S E E L E D K D S K S K K P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507187 1282 144754 A200 E E M E N K D A K S K K A Q A
Chicken Gallus gallus NP_001033585 1220 137737 R121 E E M E D K D R K S K K T Q K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923573 1166 130209 N148 G D E D Q G Q N D M E N E H R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651974 1144 127185 S111 D E P A A Q E S Q S E K E E K
Honey Bee Apis mellifera XP_392101 1028 116618 A100 E V G T V K T A A Q K K K E K
Nematode Worm Caenorhab. elegans NP_497536 1074 120399 E96 K P E K E K K E K K K A G K K
Sea Urchin Strong. purpuratus XP_001199006 1349 151384 E134 S G V G Q A A E E T P E T S E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_177807 1294 142098 E184 E V H E D E E E E S P I T F S
Baker's Yeast Sacchar. cerevisiae P39730 1002 112250 K96 K S K K E K E K E K K E K E K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 79.2 96 N.A. 91.6 90 N.A. 82.2 84.5 N.A. 64.3 N.A. 50.8 53.6 40.3 43.5
Protein Similarity: 100 99.7 79.7 97.8 N.A. 95.1 94.5 N.A. 87.6 90.5 N.A. 75.4 N.A. 66.7 67.7 61.1 62.7
P-Site Identity: 100 100 100 93.3 N.A. 13.3 13.3 N.A. 60 80 N.A. 0 N.A. 33.3 33.3 26.6 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 20 20 N.A. 80 86.6 N.A. 33.3 N.A. 66.6 40 46.6 46.6
Percent
Protein Identity: N.A. N.A. N.A. 38.3 39.1 N.A.
Protein Similarity: N.A. N.A. N.A. 57.9 57.5 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 7 7 7 14 7 0 0 7 7 27 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 7 40 14 40 14 7 0 0 0 0 0 0 % D
% Glu: 54 60 27 47 27 7 20 20 20 0 14 14 14 20 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 7 7 7 7 0 7 0 0 0 0 0 0 7 0 0 % G
% His: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 14 0 7 14 0 60 20 7 47 27 60 67 27 7 60 % K
% Leu: 0 0 20 14 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 14 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 0 7 0 0 0 7 0 0 0 % N
% Pro: 0 7 7 0 0 0 0 0 0 0 14 0 0 7 0 % P
% Gln: 0 0 0 0 14 7 7 0 7 7 0 0 0 14 0 % Q
% Arg: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 7 % R
% Ser: 20 7 0 0 0 0 0 34 14 54 14 0 0 7 7 % S
% Thr: 0 0 0 7 0 0 7 0 0 7 0 0 47 7 0 % T
% Val: 0 14 7 0 7 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _