KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5B
All Species:
19.09
Human Site:
S460
Identified Species:
30
UniProt:
O60841
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60841
NP_056988.3
1220
138827
S460
K
I
P
Q
Q
L
E
S
K
E
V
S
E
S
M
Chimpanzee
Pan troglodytes
XP_001159716
1220
138677
S460
K
I
P
Q
Q
L
E
S
K
E
V
S
E
S
M
Rhesus Macaque
Macaca mulatta
XP_001103720
1526
171398
S765
K
I
P
Q
Q
L
E
S
K
E
V
S
E
S
M
Dog
Lupus familis
XP_851262
1220
138726
N460
K
T
L
Q
Q
L
E
N
K
E
V
S
E
P
I
Cat
Felis silvestris
Mouse
Mus musculus
Q05D44
1216
137597
S459
K
T
P
Q
Q
L
E
S
K
E
V
S
E
T
L
Rat
Rattus norvegicus
B2GUV7
1216
137668
S459
K
T
P
Q
Q
L
E
S
K
E
A
L
E
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507187
1282
144754
N530
K
P
Q
Q
Q
Q
E
N
K
E
V
S
E
Q
I
Chicken
Gallus gallus
NP_001033585
1220
137737
K453
K
Q
Q
Q
P
E
N
K
E
V
S
E
S
L
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923573
1166
130209
A421
E
G
K
L
L
T
K
A
Q
K
E
A
R
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651974
1144
127185
T372
K
A
E
G
K
L
L
T
K
K
Q
K
E
D
R
Honey Bee
Apis mellifera
XP_392101
1028
116618
E343
I
I
D
Q
Q
S
K
E
S
E
E
K
E
D
D
Nematode Worm
Caenorhab. elegans
NP_497536
1074
120399
E335
E
K
T
K
A
K
Q
E
E
K
K
R
R
R
L
Sea Urchin
Strong. purpuratus
XP_001199006
1349
151384
A581
E
E
A
K
Q
K
A
A
E
E
A
E
E
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177807
1294
142098
G504
Q
L
L
A
A
G
G
G
L
P
V
A
D
N
D
Baker's Yeast
Sacchar. cerevisiae
P39730
1002
112250
N338
D
D
D
E
E
G
T
N
E
E
T
Q
E
S
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
79.2
96
N.A.
91.6
90
N.A.
82.2
84.5
N.A.
64.3
N.A.
50.8
53.6
40.3
43.5
Protein Similarity:
100
99.7
79.7
97.8
N.A.
95.1
94.5
N.A.
87.6
90.5
N.A.
75.4
N.A.
66.7
67.7
61.1
62.7
P-Site Identity:
100
100
100
66.6
N.A.
80
66.6
N.A.
60
13.3
N.A.
0
N.A.
26.6
33.3
0
20
P-Site Similarity:
100
100
100
80
N.A.
93.3
80
N.A.
73.3
20
N.A.
46.6
N.A.
46.6
40
40
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.3
39.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.9
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
14
0
7
14
0
0
14
14
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
14
0
0
0
0
0
0
0
0
0
7
14
14
% D
% Glu:
20
7
7
7
7
7
47
14
27
67
14
14
74
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
7
0
14
7
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
27
0
0
0
0
0
0
0
0
0
0
0
0
14
% I
% Lys:
60
7
7
14
7
14
14
7
54
20
7
14
0
0
0
% K
% Leu:
0
7
14
7
7
47
7
0
7
0
0
7
0
14
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% M
% Asn:
0
0
0
0
0
0
7
20
0
0
0
0
0
7
0
% N
% Pro:
0
7
34
0
7
0
0
0
0
7
0
0
0
7
0
% P
% Gln:
7
7
14
60
60
7
7
0
7
0
7
7
0
7
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
7
14
7
20
% R
% Ser:
0
0
0
0
0
7
0
34
7
0
7
40
7
27
0
% S
% Thr:
0
20
7
0
0
7
7
7
0
0
7
0
0
14
7
% T
% Val:
0
0
0
0
0
0
0
0
0
7
47
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _