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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5B
All Species:
30.61
Human Site:
S591
Identified Species:
48.1
UniProt:
O60841
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60841
NP_056988.3
1220
138827
S591
S
K
E
M
S
S
D
S
E
Y
D
S
D
D
D
Chimpanzee
Pan troglodytes
XP_001159716
1220
138677
S591
S
K
E
M
S
S
D
S
E
Y
D
S
D
D
D
Rhesus Macaque
Macaca mulatta
XP_001103720
1526
171398
S897
S
K
E
M
S
S
D
S
E
Y
D
S
D
D
D
Dog
Lupus familis
XP_851262
1220
138726
S591
S
K
E
M
S
S
E
S
E
Y
D
S
D
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q05D44
1216
137597
S587
S
K
D
A
S
S
D
S
E
Y
D
S
D
D
D
Rat
Rattus norvegicus
B2GUV7
1216
137668
S587
N
K
D
A
S
S
D
S
E
Y
D
S
D
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507187
1282
144754
S653
S
K
E
A
S
S
E
S
E
S
D
S
D
D
D
Chicken
Gallus gallus
NP_001033585
1220
137737
S591
S
K
E
I
S
S
D
S
E
Y
D
S
D
D
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923573
1166
130209
E548
T
E
E
N
G
S
E
E
E
E
D
E
D
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651974
1144
127185
D515
D
S
D
G
D
S
D
D
S
R
E
V
S
V
L
Honey Bee
Apis mellifera
XP_392101
1028
116618
N463
L
D
K
L
R
R
T
N
V
Q
D
G
E
A
G
Nematode Worm
Caenorhab. elegans
NP_497536
1074
120399
Q451
D
E
D
R
G
G
Q
Q
K
E
T
V
E
E
R
Sea Urchin
Strong. purpuratus
XP_001199006
1349
151384
D720
K
E
S
W
D
A
E
D
D
V
A
D
N
W
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177807
1294
142098
H639
K
D
A
I
S
K
A
H
D
S
E
P
E
A
E
Baker's Yeast
Sacchar. cerevisiae
P39730
1002
112250
A454
F
P
I
D
A
I
K
A
K
T
K
V
M
A
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
79.2
96
N.A.
91.6
90
N.A.
82.2
84.5
N.A.
64.3
N.A.
50.8
53.6
40.3
43.5
Protein Similarity:
100
99.7
79.7
97.8
N.A.
95.1
94.5
N.A.
87.6
90.5
N.A.
75.4
N.A.
66.7
67.7
61.1
62.7
P-Site Identity:
100
100
100
93.3
N.A.
86.6
80
N.A.
80
93.3
N.A.
33.3
N.A.
13.3
6.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
100
N.A.
66.6
N.A.
26.6
33.3
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.3
39.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.9
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
20
7
7
7
7
0
0
7
0
0
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
14
27
7
14
0
47
14
14
0
67
7
60
54
54
% D
% Glu:
0
20
47
0
0
0
27
7
60
14
14
7
20
14
27
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
14
7
0
0
0
0
0
7
0
0
7
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
14
0
7
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
54
7
0
0
7
7
0
14
0
7
0
0
0
0
% K
% Leu:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% L
% Met:
0
0
0
27
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
7
0
0
7
0
0
0
7
0
0
0
0
7
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
7
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
7
7
7
0
0
0
7
0
0
0
0
7
% R
% Ser:
47
7
7
0
60
67
0
54
7
14
0
54
7
0
0
% S
% Thr:
7
0
0
0
0
0
7
0
0
7
7
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
7
7
0
20
0
7
0
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
47
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _