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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIAPH2
All Species:
26.67
Human Site:
S175
Identified Species:
48.89
UniProt:
O60879
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60879
NP_006720.1
1101
125569
S175
H
E
L
R
S
G
I
S
D
E
K
L
L
N
C
Chimpanzee
Pan troglodytes
XP_509808
1253
142880
A249
H
E
L
K
M
G
S
A
D
E
R
L
V
T
C
Rhesus Macaque
Macaca mulatta
XP_001087983
1101
125595
S175
H
E
L
R
S
G
I
S
D
E
K
L
L
N
C
Dog
Lupus familis
XP_857344
981
113022
T164
P
E
H
P
S
M
M
T
D
V
V
K
L
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z207
1171
133668
T167
H
E
L
K
M
G
Y
T
D
E
R
L
F
T
Y
Rat
Rattus norvegicus
XP_001066898
1064
121036
S177
H
E
L
R
S
G
I
S
D
E
K
L
L
N
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512687
1111
126766
T197
H
E
L
R
S
G
I
T
E
D
K
L
L
N
C
Chicken
Gallus gallus
XP_417020
1172
133968
T160
Q
E
L
K
S
G
S
T
D
E
R
L
V
T
C
Frog
Xenopus laevis
Q6NTV6
1099
121463
V180
N
Q
Q
Y
R
F
S
V
I
T
N
E
L
S
S
Zebra Danio
Brachydanio rerio
XP_683813
932
105075
S160
H
E
L
R
S
G
I
S
E
D
K
L
L
N
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48608
1091
123153
E159
N
P
I
S
W
I
K
E
F
G
V
A
G
I
G
Honey Bee
Apis mellifera
XP_395654
1140
128906
L160
Q
E
F
G
T
K
G
L
K
Q
V
L
A
T
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_800685
1168
130533
D232
L
H
S
T
A
A
S
D
T
G
R
Y
H
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.2
98.4
53
N.A.
53.2
82.1
N.A.
79.2
54.8
21.4
60.6
N.A.
40.8
41.6
N.A.
34.4
Protein Similarity:
100
68.2
99.5
70.5
N.A.
71.2
88.2
N.A.
87.6
71.6
41.2
72.1
N.A.
61
61.4
N.A.
53
P-Site Identity:
100
53.3
100
26.6
N.A.
46.6
100
N.A.
80
53.3
6.6
86.6
N.A.
0
13.3
N.A.
0
P-Site Similarity:
100
80
100
40
N.A.
66.6
100
N.A.
100
80
26.6
100
N.A.
13.3
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
8
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% C
% Asp:
0
0
0
0
0
0
0
8
54
16
0
0
0
0
0
% D
% Glu:
0
77
0
0
0
0
0
8
16
47
0
8
0
0
0
% E
% Phe:
0
0
8
0
0
8
0
0
8
0
0
0
8
0
0
% F
% Gly:
0
0
0
8
0
62
8
0
0
16
0
0
8
0
8
% G
% His:
54
8
8
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
8
39
0
8
0
0
0
0
8
8
% I
% Lys:
0
0
0
24
0
8
8
0
8
0
39
8
0
0
0
% K
% Leu:
8
0
62
0
0
0
0
8
0
0
0
70
54
8
8
% L
% Met:
0
0
0
0
16
8
8
0
0
0
0
0
0
0
0
% M
% Asn:
16
0
0
0
0
0
0
0
0
0
8
0
0
39
0
% N
% Pro:
8
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
16
8
8
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
0
39
8
0
0
0
0
0
31
0
0
0
0
% R
% Ser:
0
0
8
8
54
0
31
31
0
0
0
0
0
16
16
% S
% Thr:
0
0
0
8
8
0
0
31
8
8
0
0
0
31
0
% T
% Val:
0
0
0
0
0
0
0
8
0
8
24
0
16
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _