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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIAPH2
All Species:
12.73
Human Site:
S65
Identified Species:
23.33
UniProt:
O60879
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60879
NP_006720.1
1101
125569
S65
R
I
T
S
F
R
K
S
T
V
K
K
E
K
P
Chimpanzee
Pan troglodytes
XP_509808
1253
142880
P142
K
F
A
S
I
R
I
P
G
S
K
K
E
R
P
Rhesus Macaque
Macaca mulatta
XP_001087983
1101
125595
S65
R
I
T
S
F
R
K
S
T
V
K
K
E
K
P
Dog
Lupus familis
XP_857344
981
113022
E68
L
K
M
G
S
A
D
E
R
L
V
T
C
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z207
1171
133668
E65
R
I
P
G
S
K
K
E
R
P
P
L
P
H
L
Rat
Rattus norvegicus
XP_001066898
1064
121036
S67
R
I
T
S
F
R
K
S
A
I
K
K
E
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512687
1111
126766
S87
R
I
T
S
F
R
K
S
A
V
K
K
E
K
L
Chicken
Gallus gallus
XP_417020
1172
133968
M66
E
R
P
A
L
P
H
M
K
Q
S
H
S
T
D
Frog
Xenopus laevis
Q6NTV6
1099
121463
M65
E
S
S
D
D
E
W
M
C
Q
F
L
E
L
S
Zebra Danio
Brachydanio rerio
XP_683813
932
105075
I66
I
Q
H
P
T
D
P
I
S
T
Q
T
E
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48608
1091
123153
A65
Y
I
Q
Q
L
S
V
A
E
L
D
A
K
F
L
Honey Bee
Apis mellifera
XP_395654
1140
128906
N64
I
E
R
M
D
K
E
N
S
N
D
K
F
E
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_800685
1168
130533
D99
E
N
G
S
V
T
D
D
S
I
L
D
D
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.2
98.4
53
N.A.
53.2
82.1
N.A.
79.2
54.8
21.4
60.6
N.A.
40.8
41.6
N.A.
34.4
Protein Similarity:
100
68.2
99.5
70.5
N.A.
71.2
88.2
N.A.
87.6
71.6
41.2
72.1
N.A.
61
61.4
N.A.
53
P-Site Identity:
100
40
100
0
N.A.
20
86.6
N.A.
86.6
0
6.6
13.3
N.A.
6.6
6.6
N.A.
6.6
P-Site Similarity:
100
53.3
100
6.6
N.A.
26.6
93.3
N.A.
86.6
6.6
13.3
26.6
N.A.
26.6
40
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
8
0
8
16
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% C
% Asp:
0
0
0
8
16
8
16
8
0
0
16
8
8
0
8
% D
% Glu:
24
8
0
0
0
8
8
16
8
0
0
0
54
8
16
% E
% Phe:
0
8
0
0
31
0
0
0
0
0
8
0
8
8
0
% F
% Gly:
0
0
8
16
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
8
0
0
0
0
8
0
8
0
% H
% Ile:
16
47
0
0
8
0
8
8
0
16
0
0
0
0
0
% I
% Lys:
8
8
0
0
0
16
39
0
8
0
39
47
8
31
0
% K
% Leu:
8
0
0
0
16
0
0
0
0
16
8
16
0
24
24
% L
% Met:
0
0
8
8
0
0
0
16
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
8
0
8
0
0
0
0
0
% N
% Pro:
0
0
16
8
0
8
8
8
0
8
8
0
8
0
39
% P
% Gln:
0
8
8
8
0
0
0
0
0
16
8
0
0
0
0
% Q
% Arg:
39
8
8
0
0
39
0
0
16
0
0
0
0
8
0
% R
% Ser:
0
8
8
47
16
8
0
31
24
8
8
0
8
8
8
% S
% Thr:
0
0
31
0
8
8
0
0
16
8
0
16
0
8
0
% T
% Val:
0
0
0
0
8
0
8
0
0
24
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _