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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D1A
All Species:
14.55
Human Site:
S85
Identified Species:
45.71
UniProt:
O60880
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60880
NP_001108409.1
128
14187
S85
R
K
I
K
N
L
I
S
A
F
Q
K
P
D
Q
Chimpanzee
Pan troglodytes
XP_001142550
79
8984
Q42
K
N
L
I
S
A
F
Q
K
P
D
Q
G
I
V
Rhesus Macaque
Macaca mulatta
XP_001118174
132
15284
V95
K
P
N
Q
G
M
V
V
H
L
L
K
P
I
K
Dog
Lupus familis
XP_852122
128
14241
S85
R
K
I
K
N
L
I
S
A
F
Q
K
P
D
Q
Cat
Felis silvestris
Mouse
Mus musculus
O88890
126
13885
S85
R
K
V
K
N
L
I
S
A
F
Q
K
P
D
Q
Rat
Rattus norvegicus
B2RZ59
126
13973
S85
R
K
V
K
N
L
I
S
A
F
Q
K
P
D
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090449
110
12391
T73
A
E
A
A
P
G
V
T
R
R
L
F
R
K
V
Zebra Danio
Brachydanio rerio
XP_001920648
108
11958
G71
W
A
A
E
T
A
P
G
Q
T
K
R
L
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.7
37.8
93.7
N.A.
87.5
89
N.A.
N.A.
N.A.
57
54.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
61.7
61.3
94.5
N.A.
89.8
91.4
N.A.
N.A.
N.A.
71
64.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
13.3
100
N.A.
93.3
93.3
N.A.
N.A.
N.A.
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
46.6
100
N.A.
100
100
N.A.
N.A.
N.A.
20
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
13
25
13
0
25
0
0
50
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
13
0
0
50
0
% D
% Glu:
0
13
0
13
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
13
0
0
50
0
13
0
13
0
% F
% Gly:
0
0
0
0
13
13
0
13
0
0
0
0
13
0
0
% G
% His:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% H
% Ile:
0
0
25
13
0
0
50
0
0
0
0
0
0
25
0
% I
% Lys:
25
50
0
50
0
0
0
0
13
0
13
63
0
13
13
% K
% Leu:
0
0
13
0
0
50
0
0
0
13
25
0
13
0
0
% L
% Met:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
13
0
50
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
13
0
0
13
0
13
0
0
13
0
0
63
0
0
% P
% Gln:
0
0
0
13
0
0
0
13
13
0
50
13
0
0
50
% Q
% Arg:
50
0
0
0
0
0
0
0
13
13
0
13
13
0
13
% R
% Ser:
0
0
0
0
13
0
0
50
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
13
0
0
13
0
13
0
0
0
0
0
% T
% Val:
0
0
25
0
0
0
25
13
0
0
0
0
0
0
25
% V
% Trp:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _