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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD2
All Species:
24.24
Human Site:
S270
Identified Species:
44.44
UniProt:
O60906
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60906
NP_003071.2
423
47646
S270
P
H
R
G
T
P
L
S
D
H
E
A
L
M
A
Chimpanzee
Pan troglodytes
XP_001151885
423
47551
S270
P
H
S
G
T
P
L
S
D
H
E
A
L
M
A
Rhesus Macaque
Macaca mulatta
XP_001090569
423
47701
S270
P
Y
S
G
T
P
L
S
D
H
E
A
L
M
A
Dog
Lupus familis
XP_539078
356
39289
E241
R
L
I
S
V
L
K
E
A
W
T
E
L
D
L
Cat
Felis silvestris
Mouse
Mus musculus
O70572
419
47448
S270
P
H
S
D
K
P
F
S
D
H
E
A
L
M
A
Rat
Rattus norvegicus
Q9ET64
422
47626
S270
P
H
N
G
T
P
F
S
D
H
E
A
L
M
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232516
410
45711
S270
P
G
M
D
I
P
Y
S
D
H
E
A
V
M
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001338369
436
48730
S270
P
G
Q
P
F
P
Y
S
D
H
E
A
L
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZS6
442
49624
F261
V
P
G
E
K
F
S
F
S
D
H
E
A
V
M
Honey Bee
Apis mellifera
XP_395633
385
43675
Y264
I
P
Y
K
N
F
S
Y
S
D
H
E
A
I
M
Nematode Worm
Caenorhab. elegans
O45870
434
49845
D317
G
E
D
L
N
Y
S
D
H
V
G
L
R
A
R
Sea Urchin
Strong. purpuratus
XP_794902
212
24247
G97
Y
H
P
Y
S
L
N
G
Y
A
H
K
V
T
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40015
477
53922
S332
P
H
L
D
C
S
V
S
D
H
F
A
Y
S
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.9
71.8
N.A.
76.3
78.9
N.A.
N.A.
47.9
N.A.
42.2
N.A.
27.8
35.2
30.1
21.5
Protein Similarity:
100
99.5
97.6
76.1
N.A.
84.8
86
N.A.
N.A.
64
N.A.
59.1
N.A.
45
51.5
47.4
33.8
P-Site Identity:
100
93.3
86.6
6.6
N.A.
73.3
86.6
N.A.
N.A.
60
N.A.
60
N.A.
0
0
0
6.6
P-Site Similarity:
100
93.3
93.3
6.6
N.A.
73.3
86.6
N.A.
N.A.
66.6
N.A.
66.6
N.A.
6.6
6.6
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
8
0
62
16
8
54
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
8
24
0
0
0
8
62
16
0
0
0
8
0
% D
% Glu:
0
8
0
8
0
0
0
8
0
0
54
24
0
0
0
% E
% Phe:
0
0
0
0
8
16
16
8
0
0
8
0
0
0
0
% F
% Gly:
8
16
8
31
0
0
0
8
0
0
8
0
0
0
0
% G
% His:
0
47
0
0
0
0
0
0
8
62
24
0
0
0
0
% H
% Ile:
8
0
8
0
8
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
8
16
0
8
0
0
0
0
8
0
0
0
% K
% Leu:
0
8
8
8
0
16
24
0
0
0
0
8
54
0
8
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
47
24
% M
% Asn:
0
0
8
0
16
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
62
16
8
8
0
54
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
8
0
0
0
0
0
0
0
0
0
8
0
8
% R
% Ser:
0
0
24
8
8
8
24
62
16
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
31
0
0
0
0
0
8
0
0
16
0
% T
% Val:
8
0
0
0
8
0
8
0
0
8
0
0
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
8
8
8
0
8
16
8
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _