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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD2
All Species:
18.18
Human Site:
S284
Identified Species:
33.33
UniProt:
O60906
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60906
NP_003071.2
423
47646
S284
A
T
L
F
V
R
H
S
P
P
Q
Q
N
P
S
Chimpanzee
Pan troglodytes
XP_001151885
423
47551
S284
A
T
L
F
V
R
H
S
P
P
Q
Q
N
P
S
Rhesus Macaque
Macaca mulatta
XP_001090569
423
47701
S284
A
T
L
F
V
R
H
S
P
P
Q
Q
S
P
N
Dog
Lupus familis
XP_539078
356
39289
W255
L
G
V
A
Q
A
R
W
W
A
T
F
A
G
Y
Cat
Felis silvestris
Mouse
Mus musculus
O70572
419
47448
S284
A
T
L
Y
V
K
H
S
P
P
Q
E
D
P
C
Rat
Rattus norvegicus
Q9ET64
422
47626
S284
A
T
L
C
V
K
H
S
P
P
Q
E
D
P
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232516
410
45711
R284
A
M
L
C
I
Q
R
R
G
R
A
A
G
A
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001338369
436
48730
T284
A
Q
F
L
F
T
P
T
K
K
G
N
K
C
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZS6
442
49624
K275
M
A
K
L
K
L
F
K
L
E
P
R
S
E
E
Honey Bee
Apis mellifera
XP_395633
385
43675
I278
M
A
T
F
K
F
S
I
D
I
K
D
S
L
K
Nematode Worm
Caenorhab. elegans
O45870
434
49845
F331
R
F
T
I
D
D
R
F
R
H
E
K
S
V
N
Sea Urchin
Strong. purpuratus
XP_794902
212
24247
K111
M
A
D
W
Y
I
S
K
M
V
A
L
C
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40015
477
53922
Q346
C
T
L
N
I
V
P
Q
G
T
E
S
R
P
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.9
71.8
N.A.
76.3
78.9
N.A.
N.A.
47.9
N.A.
42.2
N.A.
27.8
35.2
30.1
21.5
Protein Similarity:
100
99.5
97.6
76.1
N.A.
84.8
86
N.A.
N.A.
64
N.A.
59.1
N.A.
45
51.5
47.4
33.8
P-Site Identity:
100
100
86.6
0
N.A.
66.6
66.6
N.A.
N.A.
13.3
N.A.
6.6
N.A.
0
6.6
0
0
P-Site Similarity:
100
100
100
6.6
N.A.
93.3
86.6
N.A.
N.A.
33.3
N.A.
20
N.A.
13.3
20
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
54
24
0
8
0
8
0
0
0
8
16
8
8
8
8
% A
% Cys:
8
0
0
16
0
0
0
0
0
0
0
0
8
8
16
% C
% Asp:
0
0
8
0
8
8
0
0
8
0
0
8
16
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
16
16
0
8
8
% E
% Phe:
0
8
8
31
8
8
8
8
0
0
0
8
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
16
0
8
0
8
8
0
% G
% His:
0
0
0
0
0
0
39
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
16
8
0
8
0
8
0
0
0
0
0
% I
% Lys:
0
0
8
0
16
16
0
16
8
8
8
8
8
8
8
% K
% Leu:
8
0
54
16
0
8
0
0
8
0
0
8
0
8
8
% L
% Met:
24
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
8
16
0
16
% N
% Pro:
0
0
0
0
0
0
16
0
39
39
8
0
0
47
0
% P
% Gln:
0
8
0
0
8
8
0
8
0
0
39
24
0
0
0
% Q
% Arg:
8
0
0
0
0
24
24
8
8
8
0
8
8
0
0
% R
% Ser:
0
0
0
0
0
0
16
39
0
0
0
8
31
0
24
% S
% Thr:
0
47
16
0
0
8
0
8
0
8
8
0
0
0
8
% T
% Val:
0
0
8
0
39
8
0
0
0
8
0
0
0
8
0
% V
% Trp:
0
0
0
8
0
0
0
8
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _