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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMPD2 All Species: 19.39
Human Site: S292 Identified Species: 35.56
UniProt: O60906 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60906 NP_003071.2 423 47646 S292 P P Q Q N P S S T H G P A E R
Chimpanzee Pan troglodytes XP_001151885 423 47551 S292 P P Q Q N P S S T H G P A E R
Rhesus Macaque Macaca mulatta XP_001090569 423 47701 S292 P P Q Q S P N S T H R P A E R
Dog Lupus familis XP_539078 356 39289 V263 W A T F A G Y V I G L G L L L
Cat Felis silvestris
Mouse Mus musculus O70572 419 47448 T292 P P Q E D P C T A C G P L E R
Rat Rattus norvegicus Q9ET64 422 47626 S292 P P Q E D P C S A H G S A E R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232516 410 45711 I292 G R A A G A T I G T A M P A L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001338369 436 48730 E292 K K G N K C A E N K S G C V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZS6 442 49624 P283 L E P R S E E P V A T I E V N
Honey Bee Apis mellifera XP_395633 385 43675 E286 D I K D S L K E A I N I C E T
Nematode Worm Caenorhab. elegans O45870 434 49845 T339 R H E K S V N T W E P N R P L
Sea Urchin Strong. purpuratus XP_794902 212 24247 D119 M V A L C K L D V E G M T V N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40015 477 53922 T354 G T E S R P S T S V K R A K T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 95.9 71.8 N.A. 76.3 78.9 N.A. N.A. 47.9 N.A. 42.2 N.A. 27.8 35.2 30.1 21.5
Protein Similarity: 100 99.5 97.6 76.1 N.A. 84.8 86 N.A. N.A. 64 N.A. 59.1 N.A. 45 51.5 47.4 33.8
P-Site Identity: 100 100 80 0 N.A. 53.3 66.6 N.A. N.A. 0 N.A. 0 N.A. 0 6.6 0 6.6
P-Site Similarity: 100 100 93.3 0 N.A. 73.3 80 N.A. N.A. 6.6 N.A. 6.6 N.A. 13.3 20 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 16 8 8 8 8 0 24 8 8 0 39 8 0 % A
% Cys: 0 0 0 0 8 8 16 0 0 8 0 0 16 0 0 % C
% Asp: 8 0 0 8 16 0 0 8 0 0 0 0 0 0 0 % D
% Glu: 0 8 16 16 0 8 8 16 0 16 0 0 8 47 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 16 0 8 0 8 8 0 0 8 8 39 16 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 31 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 8 8 8 0 16 0 0 0 % I
% Lys: 8 8 8 8 8 8 8 0 0 8 8 0 0 8 0 % K
% Leu: 8 0 0 8 0 8 8 0 0 0 8 0 16 8 31 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 16 0 0 0 % M
% Asn: 0 0 0 8 16 0 16 0 8 0 8 8 0 0 16 % N
% Pro: 39 39 8 0 0 47 0 8 0 0 8 31 8 8 0 % P
% Gln: 0 0 39 24 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 8 0 8 8 0 0 0 0 0 8 8 8 0 39 % R
% Ser: 0 0 0 8 31 0 24 31 8 0 8 8 0 0 0 % S
% Thr: 0 8 8 0 0 0 8 24 24 8 8 0 8 0 16 % T
% Val: 0 8 0 0 0 8 0 8 16 8 0 0 0 24 0 % V
% Trp: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _