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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD2
All Species:
15.45
Human Site:
S300
Identified Species:
28.33
UniProt:
O60906
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60906
NP_003071.2
423
47646
S300
T
H
G
P
A
E
R
S
P
L
M
C
V
L
K
Chimpanzee
Pan troglodytes
XP_001151885
423
47551
S300
T
H
G
P
A
E
R
S
P
L
M
C
V
L
K
Rhesus Macaque
Macaca mulatta
XP_001090569
423
47701
S300
T
H
R
P
A
E
R
S
P
L
M
S
V
L
K
Dog
Lupus familis
XP_539078
356
39289
L271
I
G
L
G
L
L
L
L
A
L
L
C
A
L
A
Cat
Felis silvestris
Mouse
Mus musculus
O70572
419
47448
S300
A
C
G
P
L
E
R
S
D
L
I
S
V
L
R
Rat
Rattus norvegicus
Q9ET64
422
47626
S300
A
H
G
S
A
E
R
S
A
L
I
S
A
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232516
410
45711
V300
G
T
A
M
P
A
L
V
E
V
L
S
E
A
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001338369
436
48730
D300
N
K
S
G
C
V
L
D
D
L
P
E
L
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZS6
442
49624
C291
V
A
T
I
E
V
N
C
L
V
E
D
G
E
T
Honey Bee
Apis mellifera
XP_395633
385
43675
S294
A
I
N
I
C
E
T
S
L
K
N
V
R
R
Q
Nematode Worm
Caenorhab. elegans
O45870
434
49845
L347
W
E
P
N
R
P
L
L
I
E
A
I
G
L
V
Sea Urchin
Strong. purpuratus
XP_794902
212
24247
V127
V
E
G
M
T
V
N
V
Y
N
T
H
A
H
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40015
477
53922
H362
S
V
K
R
A
K
T
H
D
R
E
L
I
L
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.9
71.8
N.A.
76.3
78.9
N.A.
N.A.
47.9
N.A.
42.2
N.A.
27.8
35.2
30.1
21.5
Protein Similarity:
100
99.5
97.6
76.1
N.A.
84.8
86
N.A.
N.A.
64
N.A.
59.1
N.A.
45
51.5
47.4
33.8
P-Site Identity:
100
100
86.6
20
N.A.
53.3
53.3
N.A.
N.A.
0
N.A.
6.6
N.A.
0
13.3
6.6
6.6
P-Site Similarity:
100
100
86.6
26.6
N.A.
66.6
66.6
N.A.
N.A.
20
N.A.
20
N.A.
6.6
20
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
8
8
0
39
8
0
0
16
0
8
0
24
8
16
% A
% Cys:
0
8
0
0
16
0
0
8
0
0
0
24
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
24
0
0
8
0
0
0
% D
% Glu:
0
16
0
0
8
47
0
0
8
8
16
8
8
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
39
16
0
0
0
0
0
0
0
0
16
0
0
% G
% His:
0
31
0
0
0
0
0
8
0
0
0
8
0
8
0
% H
% Ile:
8
8
0
16
0
0
0
0
8
0
16
8
8
0
0
% I
% Lys:
0
8
8
0
0
8
0
0
0
8
0
0
0
0
24
% K
% Leu:
0
0
8
0
16
8
31
16
16
54
16
8
8
62
0
% L
% Met:
0
0
0
16
0
0
0
0
0
0
24
0
0
0
0
% M
% Asn:
8
0
8
8
0
0
16
0
0
8
8
0
0
0
8
% N
% Pro:
0
0
8
31
8
8
0
0
24
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% Q
% Arg:
0
0
8
8
8
0
39
0
0
8
0
0
8
8
24
% R
% Ser:
8
0
8
8
0
0
0
47
0
0
0
31
0
0
0
% S
% Thr:
24
8
8
0
8
0
16
0
0
0
8
0
0
0
8
% T
% Val:
16
8
0
0
0
24
0
16
0
16
0
8
31
8
8
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _