KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD2
All Species:
19.09
Human Site:
T258
Identified Species:
35
UniProt:
O60906
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60906
NP_003071.2
423
47646
T258
S
C
K
S
F
E
T
T
T
G
F
D
P
H
R
Chimpanzee
Pan troglodytes
XP_001151885
423
47551
T258
S
C
K
S
L
E
T
T
T
G
F
D
P
H
S
Rhesus Macaque
Macaca mulatta
XP_001090569
423
47701
T258
S
C
K
S
L
E
T
T
T
G
N
D
P
Y
S
Dog
Lupus familis
XP_539078
356
39289
P229
T
P
D
P
T
Q
G
P
A
E
R
S
R
L
I
Cat
Felis silvestris
Mouse
Mus musculus
O70572
419
47448
T258
C
C
E
T
L
K
T
T
T
G
C
D
P
H
S
Rat
Rattus norvegicus
Q9ET64
422
47626
T258
C
C
K
T
L
K
T
T
T
G
C
D
P
H
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232516
410
45711
T258
K
C
E
E
L
R
T
T
T
G
T
V
P
G
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001338369
436
48730
T258
S
C
E
S
L
S
T
T
K
G
P
V
P
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZS6
442
49624
P249
E
I
A
E
Y
K
L
P
F
P
E
R
V
P
G
Honey Bee
Apis mellifera
XP_395633
385
43675
P252
E
I
I
N
F
Q
H
P
F
P
N
R
I
P
Y
Nematode Worm
Caenorhab. elegans
O45870
434
49845
L305
L
E
E
C
E
I
T
L
N
Q
I
P
G
E
D
Sea Urchin
Strong. purpuratus
XP_794902
212
24247
I85
C
I
F
S
K
W
P
I
I
D
T
F
Y
H
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40015
477
53922
F320
T
V
D
A
G
V
R
F
T
E
R
I
P
H
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.9
71.8
N.A.
76.3
78.9
N.A.
N.A.
47.9
N.A.
42.2
N.A.
27.8
35.2
30.1
21.5
Protein Similarity:
100
99.5
97.6
76.1
N.A.
84.8
86
N.A.
N.A.
64
N.A.
59.1
N.A.
45
51.5
47.4
33.8
P-Site Identity:
100
86.6
73.3
0
N.A.
53.3
60
N.A.
N.A.
40
N.A.
46.6
N.A.
0
6.6
6.6
13.3
P-Site Similarity:
100
86.6
80
13.3
N.A.
73.3
73.3
N.A.
N.A.
46.6
N.A.
60
N.A.
13.3
20
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% A
% Cys:
24
54
0
8
0
0
0
0
0
0
16
0
0
0
0
% C
% Asp:
0
0
16
0
0
0
0
0
0
8
0
39
0
0
8
% D
% Glu:
16
8
31
16
8
24
0
0
0
16
8
0
0
8
0
% E
% Phe:
0
0
8
0
16
0
0
8
16
0
16
8
0
0
0
% F
% Gly:
0
0
0
0
8
0
8
0
0
54
0
0
8
16
8
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
47
0
% H
% Ile:
0
24
8
0
0
8
0
8
8
0
8
8
8
0
8
% I
% Lys:
8
0
31
0
8
24
0
0
8
0
0
0
0
0
0
% K
% Leu:
8
0
0
0
47
0
8
8
0
0
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
0
0
0
8
0
16
0
0
0
8
% N
% Pro:
0
8
0
8
0
0
8
24
0
16
8
8
62
16
8
% P
% Gln:
0
0
0
0
0
16
0
0
0
8
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
8
8
0
0
0
16
16
8
0
8
% R
% Ser:
31
0
0
39
0
8
0
0
0
0
0
8
0
0
24
% S
% Thr:
16
0
0
16
8
0
62
54
54
0
16
0
0
0
0
% T
% Val:
0
8
0
0
0
8
0
0
0
0
0
16
8
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
8
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _