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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUS1 All Species: 23.03
Human Site: S125 Identified Species: 50.67
UniProt: O60921 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60921 NP_004498.1 280 31691 S125 E L L S M S S S S R I V T H D
Chimpanzee Pan troglodytes XP_001152134 259 29268 P113 R I V T H D I P I K V I P R K
Rhesus Macaque Macaca mulatta XP_001088000 280 31699 S125 E L L S M S S S S R I V T H D
Dog Lupus familis XP_848291 407 45077 S252 E L L S V S S S S R V V T H D
Cat Felis silvestris
Mouse Mus musculus Q8BQY8 280 31661 S125 E L V S S S S S S R I V V H D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507001 139 15756 L24 Y A E V D I V L I P H K D P N
Chicken Gallus gallus XP_426029 271 30461 S125 E L P S L S S S S R I V T H D
Frog Xenopus laevis NP_001082564 282 32021 S125 E L P S L S S S S R I V T H D
Zebra Danio Brachydanio rerio NP_001082965 284 32061 L125 E L P S L S S L S R V V T H D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477426 278 30493 S126 I A S V L T S S S T E A R E V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786829 280 32047 H123 E L P S R T G H S R T I T H D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.5 99.2 57.2 N.A. 86 N.A. N.A. 33.2 71 71.2 64.4 N.A. 31.7 N.A. N.A. 47.5
Protein Similarity: 100 92.5 100 64.6 N.A. 92.5 N.A. N.A. 40.7 84.2 85.8 81.3 N.A. 52.8 N.A. N.A. 72.1
P-Site Identity: 100 0 100 86.6 N.A. 80 N.A. N.A. 0 86.6 86.6 73.3 N.A. 20 N.A. N.A. 53.3
P-Site Similarity: 100 40 100 100 N.A. 86.6 N.A. N.A. 6.6 93.3 93.3 86.6 N.A. 33.3 N.A. N.A. 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 0 0 0 0 0 0 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 10 0 0 0 0 0 0 10 0 73 % D
% Glu: 73 0 10 0 0 0 0 0 0 0 10 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 10 0 0 10 0 0 10 0 0 73 0 % H
% Ile: 10 10 0 0 0 10 10 0 19 0 46 19 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 10 0 0 10 % K
% Leu: 0 73 28 0 37 0 0 19 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 19 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 37 0 0 0 0 10 0 10 0 0 10 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 0 0 10 0 0 0 0 73 0 0 10 10 0 % R
% Ser: 0 0 10 73 10 64 73 64 82 0 0 0 0 0 0 % S
% Thr: 0 0 0 10 0 19 0 0 0 10 10 0 64 0 0 % T
% Val: 0 0 19 19 10 0 10 0 0 0 28 64 10 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _