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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DTNB All Species: 34.24
Human Site: S304 Identified Species: 68.48
UniProt: O60941 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60941 NP_068707.1 627 71356 S304 K K L S H A I S K S L G C V P
Chimpanzee Pan troglodytes XP_515336 627 71305 S304 K K L S H A I S K S L G C V P
Rhesus Macaque Macaca mulatta XP_001102769 743 83913 S304 K K L T N A L S K S L S C A S
Dog Lupus familis XP_540111 670 76530 S304 K K L S H A I S K S L G C V P
Cat Felis silvestris
Mouse Mus musculus O70585 700 78337 S304 K K L S H A I S K S L G C V P
Rat Rattus norvegicus P84060 654 73859 S304 K K L S H A I S K S L G C V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515697 743 83772 S304 K K L T N A L S K S L S C A S
Chicken Gallus gallus XP_419187 742 83445 S304 K K L T N A L S K S L S C A S
Frog Xenopus laevis NP_001079191 743 83797 S304 K K L S T A L S K S L S C A S
Zebra Danio Brachydanio rerio A2CI97 648 73379 S289 E S M A S L A S S A R H A L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9Y048 590 65408 H325 K Q L V H S I H K S L Q C I P
Sea Urchin Strong. purpuratus XP_797247 727 82017 K295 K K M G K A L K K P F K S P L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 64 89.5 N.A. 84 88.6 N.A. 64 64.4 64.1 21.4 N.A. N.A. N.A. 42.5 37.9
Protein Similarity: 100 100 74.2 91.7 N.A. 86.1 90.5 N.A. 74 73.8 74.6 40.4 N.A. N.A. N.A. 60.1 55.3
P-Site Identity: 100 100 60 100 N.A. 100 100 N.A. 60 60 66.6 6.6 N.A. N.A. N.A. 60 26.6
P-Site Similarity: 100 100 80 100 N.A. 100 100 N.A. 80 80 73.3 40 N.A. N.A. N.A. 80 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 84 9 0 0 9 0 0 9 34 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 84 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 0 0 9 0 0 0 0 0 0 0 42 0 0 0 % G
% His: 0 0 0 0 50 0 0 9 0 0 0 9 0 0 0 % H
% Ile: 0 0 0 0 0 0 50 0 0 0 0 0 0 9 0 % I
% Lys: 92 84 0 0 9 0 0 9 92 0 0 9 0 0 0 % K
% Leu: 0 0 84 0 0 9 42 0 0 0 84 0 0 9 9 % L
% Met: 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 9 0 0 0 9 50 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 0 9 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % R
% Ser: 0 9 0 50 9 9 0 84 9 84 0 34 9 0 34 % S
% Thr: 0 0 0 25 9 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 9 0 0 0 0 0 0 0 0 0 42 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _