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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DTNB All Species: 29.7
Human Site: S535 Identified Species: 59.39
UniProt: O60941 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60941 NP_068707.1 627 71356 S535 A T G S P H T S P T H G G G R
Chimpanzee Pan troglodytes XP_515336 627 71305 S535 A T G S P H T S P T H G G G R
Rhesus Macaque Macaca mulatta XP_001102769 743 83913 S564 G A G S P R S S P S H T I S R
Dog Lupus familis XP_540111 670 76530 S535 A T G S P H T S P T H G G G R
Cat Felis silvestris
Mouse Mus musculus O70585 700 78337 S528 A T G S P H T S P T H G G G R
Rat Rattus norvegicus P84060 654 73859 S528 A T G S P H T S P T H G G G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515697 743 83772 S564 G A G S P R S S P S H T I S R
Chicken Gallus gallus XP_419187 742 83445 S563 G A G S P R S S P S H T I S R
Frog Xenopus laevis NP_001079191 743 83797 S566 G A G S P R S S P S H T I S R
Zebra Danio Brachydanio rerio A2CI97 648 73379 T517 D L S E D I S T N L D D S E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9Y048 590 65408 Q504 Q L E H L M A Q L N T G P Q P
Sea Urchin Strong. purpuratus XP_797247 727 82017 G481 M K L L K N H G S P R N S P N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 64 89.5 N.A. 84 88.6 N.A. 64 64.4 64.1 21.4 N.A. N.A. N.A. 42.5 37.9
Protein Similarity: 100 100 74.2 91.7 N.A. 86.1 90.5 N.A. 74 73.8 74.6 40.4 N.A. N.A. N.A. 60.1 55.3
P-Site Identity: 100 100 46.6 100 N.A. 100 100 N.A. 46.6 46.6 46.6 0 N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 100 60 100 N.A. 100 100 N.A. 60 60 60 13.3 N.A. N.A. N.A. 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 42 34 0 0 0 0 9 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 9 0 0 0 0 0 9 9 0 0 0 % D
% Glu: 0 0 9 9 0 0 0 0 0 0 0 0 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 34 0 75 0 0 0 0 9 0 0 0 50 42 42 0 % G
% His: 0 0 0 9 0 42 9 0 0 0 75 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 0 0 0 0 0 34 0 0 % I
% Lys: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 17 9 9 9 0 0 0 9 9 0 0 0 0 0 % L
% Met: 9 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 0 0 9 9 0 9 0 0 9 % N
% Pro: 0 0 0 0 75 0 0 0 75 9 0 0 9 9 9 % P
% Gln: 9 0 0 0 0 0 0 9 0 0 0 0 0 9 0 % Q
% Arg: 0 0 0 0 0 34 0 0 0 0 9 0 0 0 75 % R
% Ser: 0 0 9 75 0 0 42 75 9 34 0 0 17 34 9 % S
% Thr: 0 42 0 0 0 0 42 9 0 42 9 34 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _