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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DENND4B
All Species:
25.15
Human Site:
S1278
Identified Species:
61.48
UniProt:
O75064
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75064
NP_055671.2
1496
163847
S1278
V
L
R
K
E
L
E
S
L
V
E
N
E
G
S
Chimpanzee
Pan troglodytes
XP_513830
1777
194747
S1559
V
L
R
K
E
L
E
S
L
V
E
N
E
G
S
Rhesus Macaque
Macaca mulatta
XP_001110040
1863
209085
S1649
V
V
W
K
E
L
E
S
L
L
E
N
E
G
D
Dog
Lupus familis
XP_537262
1420
155894
L1206
A
W
A
Y
L
S
P
L
V
L
R
K
E
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3U1Y4
1499
164722
S1278
V
L
R
K
E
L
E
S
L
V
E
N
E
G
S
Rat
Rattus norvegicus
XP_342288
1485
163205
S1264
V
L
R
K
E
L
E
S
L
V
E
N
E
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511528
691
77346
D490
P
A
D
V
S
C
V
D
L
D
T
N
T
I
S
Chicken
Gallus gallus
XP_413911
1870
209117
S1656
V
V
W
K
E
L
E
S
L
L
E
N
E
G
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001074458
1674
185909
S1459
V
L
W
K
E
L
E
S
L
L
E
N
E
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396776
1512
171329
E1293
P
L
M
G
A
L
V
E
L
L
D
K
P
R
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
41.1
86.2
N.A.
93.9
92.9
N.A.
28.3
42.7
N.A.
43.3
N.A.
N.A.
34.3
N.A.
N.A.
Protein Similarity:
100
83.9
56.3
88.9
N.A.
96.4
95.4
N.A.
36.4
56.2
N.A.
57.9
N.A.
N.A.
52.7
N.A.
N.A.
P-Site Identity:
100
100
73.3
6.6
N.A.
100
93.3
N.A.
20
73.3
N.A.
80
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
100
100
86.6
20
N.A.
100
93.3
N.A.
20
86.6
N.A.
86.6
N.A.
N.A.
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
0
10
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
0
10
0
10
10
0
0
0
30
% D
% Glu:
0
0
0
0
70
0
70
10
0
0
70
0
80
0
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
0
0
0
0
0
0
70
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% I
% Lys:
0
0
0
70
0
0
0
0
0
0
0
20
0
0
0
% K
% Leu:
0
60
0
0
10
80
0
10
90
50
0
0
0
10
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
80
0
0
0
% N
% Pro:
20
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
40
0
0
0
0
0
0
0
10
0
0
10
0
% R
% Ser:
0
0
0
0
10
10
0
70
0
0
0
0
0
0
40
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% T
% Val:
70
20
0
10
0
0
20
0
10
40
0
0
0
0
0
% V
% Trp:
0
10
30
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _