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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DENND4B All Species: 13.33
Human Site: S35 Identified Species: 32.59
UniProt: O75064 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75064 NP_055671.2 1496 163847 S35 E T W V P E P S G P L R P P R
Chimpanzee Pan troglodytes XP_513830 1777 194747 S318 E T W V P E P S G P L R P P R
Rhesus Macaque Macaca mulatta XP_001110040 1863 209085 D33 E E E I H F N D A C H K V A K
Dog Lupus familis XP_537262 1420 155894 A30 Y F V I A G L A G N G A P I P
Cat Felis silvestris
Mouse Mus musculus Q3U1Y4 1499 164722 T35 E K W V P E P T G P L R P P R
Rat Rattus norvegicus XP_342288 1485 163205 T35 E T W V P E P T G P L R P P R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511528 691 77346
Chicken Gallus gallus XP_413911 1870 209117 D32 E E E I H F N D A C H K I A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001074458 1674 185909 G33 E D V H P E D G A H R S S A Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396776 1512 171329 D30 D N D N E N N D Q L E D W Y Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.9 41.1 86.2 N.A. 93.9 92.9 N.A. 28.3 42.7 N.A. 43.3 N.A. N.A. 34.3 N.A. N.A.
Protein Similarity: 100 83.9 56.3 88.9 N.A. 96.4 95.4 N.A. 36.4 56.2 N.A. 57.9 N.A. N.A. 52.7 N.A. N.A.
P-Site Identity: 100 100 6.6 13.3 N.A. 86.6 93.3 N.A. 0 6.6 N.A. 20 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 100 100 26.6 26.6 N.A. 93.3 100 N.A. 0 26.6 N.A. 26.6 N.A. N.A. 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 10 30 0 0 10 0 30 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % C
% Asp: 10 10 10 0 0 0 10 30 0 0 0 10 0 0 0 % D
% Glu: 70 20 20 0 10 50 0 0 0 0 10 0 0 0 0 % E
% Phe: 0 10 0 0 0 20 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 10 0 10 50 0 10 0 0 0 0 % G
% His: 0 0 0 10 20 0 0 0 0 10 20 0 0 0 0 % H
% Ile: 0 0 0 30 0 0 0 0 0 0 0 0 10 10 0 % I
% Lys: 0 10 0 0 0 0 0 0 0 0 0 20 0 0 20 % K
% Leu: 0 0 0 0 0 0 10 0 0 10 40 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 0 10 30 0 0 10 0 0 0 0 0 % N
% Pro: 0 0 0 0 50 0 40 0 0 40 0 0 50 40 10 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 20 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 10 40 0 0 40 % R
% Ser: 0 0 0 0 0 0 0 20 0 0 0 10 10 0 0 % S
% Thr: 0 30 0 0 0 0 0 20 0 0 0 0 0 0 0 % T
% Val: 0 0 20 40 0 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 40 0 0 0 0 0 0 0 0 0 10 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _