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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATP9A All Species: 30.3
Human Site: S454 Identified Species: 55.56
UniProt: O75110 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75110 NP_006036.1 1047 118583 S454 K V R R T M S S R V H E A V K
Chimpanzee Pan troglodytes XP_514727 875 98509 D308 Y E S N G V T D Q A E A E K Q
Rhesus Macaque Macaca mulatta XP_001098852 1044 118009 S451 K V R R T M S S R V H E A V K
Dog Lupus familis XP_534457 1043 118292 S450 K V R R T M S S R V H E A V K
Cat Felis silvestris
Mouse Mus musculus O70228 1047 118590 S454 K V R R T M S S R V H E A V K
Rat Rattus norvegicus XP_002726328 995 111897 P428 D P P A Q K G P T V T T K V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509092 1116 127035 S523 K V R K T M S S R V H E A V K
Chicken Gallus gallus XP_417508 1115 125396 S522 K V R K T M S S R V H E A V K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038619 1108 125101 A501 S R K P Q P P A P K V R K S V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396589 1276 146194 T662 K V R R S E S T R I Y D A V H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_799223 1105 125600 T512 A V R R T V V T R V F E S V R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P98205 1107 124818 N438 L T V M A I C N T V L P V Q S
Baker's Yeast Sacchar. cerevisiae P40527 1151 130199 V566 R K D M S F R V R D M I L T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.5 97.8 97.4 N.A. 97.9 89.7 N.A. 90.2 89.5 N.A. 71.3 N.A. N.A. 54.3 N.A. 60.4
Protein Similarity: 100 83.5 98.2 98.2 N.A. 99.5 91.8 N.A. 92.2 91.5 N.A. 82.4 N.A. N.A. 66.8 N.A. 74.4
P-Site Identity: 100 0 100 100 N.A. 100 13.3 N.A. 93.3 93.3 N.A. 0 N.A. N.A. 53.3 N.A. 53.3
P-Site Similarity: 100 26.6 100 100 N.A. 100 20 N.A. 100 100 N.A. 13.3 N.A. N.A. 86.6 N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. 29 44.6 N.A.
Protein Similarity: N.A. N.A. N.A. 48.4 62.7 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 8 0 0 8 0 8 0 8 54 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 0 0 0 8 0 8 0 8 0 0 0 % D
% Glu: 0 8 0 0 0 8 0 0 0 0 8 54 8 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 47 0 0 0 8 % H
% Ile: 0 0 0 0 0 8 0 0 0 8 0 8 0 0 0 % I
% Lys: 54 8 8 16 0 8 0 0 0 8 0 0 16 8 47 % K
% Leu: 8 0 0 0 0 0 0 0 0 0 8 0 8 0 8 % L
% Met: 0 0 0 16 0 47 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 8 8 8 0 8 8 8 8 0 0 8 0 0 0 % P
% Gln: 0 0 0 0 16 0 0 0 8 0 0 0 0 8 8 % Q
% Arg: 8 8 62 47 0 0 8 0 70 0 0 8 0 0 16 % R
% Ser: 8 0 8 0 16 0 54 47 0 0 0 0 8 8 8 % S
% Thr: 0 8 0 0 54 0 8 16 16 0 8 8 0 8 0 % T
% Val: 0 62 8 0 0 16 8 8 0 70 8 0 8 70 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _