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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ROCK2 All Species: 13.03
Human Site: S39 Identified Species: 23.89
UniProt: O75116 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75116 NP_004841.2 1388 160900 S39 A L I R D P R S P I N V E S L
Chimpanzee Pan troglodytes P61584 1003 117506
Rhesus Macaque Macaca mulatta XP_001096931 1524 173861 S175 A L I R D P R S P I N V E S L
Dog Lupus familis XP_540083 1519 175559 S170 S D V L A L A S P R F S R Q R
Cat Felis silvestris
Mouse Mus musculus P70336 1388 160567 S39 A L I R D P R S P I N V E S L
Rat Rattus norvegicus Q62868 1379 159417 D39 I N V E S L L D G L N S L V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505615 1400 161955 Y39 F Q D D R Y L Y M V M E Y M P
Chicken Gallus gallus XP_419954 1438 166280 P88 C C S P P S L P S S L P A G A
Frog Xenopus laevis NP_001154860 1372 159002 I39 L L D G L N S I V L D L D F P
Zebra Danio Brachydanio rerio NP_777288 1375 159755 L39 L L D S M N A L V L D L D F P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W1B0 1637 186706 T44 A A E F G E D T E G H Q F S L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P92199 1173 135756 N18 V D P K S P I N I E S L L D T
Sea Urchin Strong. purpuratus XP_001198244 1323 154677 T39 E Q K A G D I T T H R L S S H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 43.3 90.4 87.8 N.A. 96.6 95.7 N.A. 82.3 86.8 82 75.2 N.A. 24.1 N.A. 34.2 47.4
Protein Similarity: 100 56.9 90.8 89.5 N.A. 98.3 97.4 N.A. 86.2 91.9 89.9 86.6 N.A. 45.2 N.A. 52.8 64.9
P-Site Identity: 100 0 100 13.3 N.A. 100 13.3 N.A. 0 0 6.6 6.6 N.A. 20 N.A. 6.6 6.6
P-Site Similarity: 100 0 100 26.6 N.A. 100 26.6 N.A. 6.6 0 33.3 33.3 N.A. 33.3 N.A. 33.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 31 8 0 8 8 0 16 0 0 0 0 0 8 0 8 % A
% Cys: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 24 8 24 8 8 8 0 0 16 0 16 8 0 % D
% Glu: 8 0 8 8 0 8 0 0 8 8 0 8 24 0 0 % E
% Phe: 8 0 0 8 0 0 0 0 0 0 8 0 8 16 0 % F
% Gly: 0 0 0 8 16 0 0 0 8 8 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 8 % H
% Ile: 8 0 24 0 0 0 16 8 8 24 0 0 0 0 0 % I
% Lys: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 16 39 0 8 8 16 24 8 0 24 8 31 16 0 39 % L
% Met: 0 0 0 0 8 0 0 0 8 0 8 0 0 8 0 % M
% Asn: 0 8 0 0 0 16 0 8 0 0 31 0 0 0 0 % N
% Pro: 0 0 8 8 8 31 0 8 31 0 0 8 0 0 24 % P
% Gln: 0 16 0 0 0 0 0 0 0 0 0 8 0 8 0 % Q
% Arg: 0 0 0 24 8 0 24 0 0 8 8 0 8 0 8 % R
% Ser: 8 0 8 8 16 8 8 31 8 8 8 16 8 39 0 % S
% Thr: 0 0 0 0 0 0 0 16 8 0 0 0 0 0 8 % T
% Val: 8 0 16 0 0 0 0 0 16 8 0 24 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 8 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _