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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
22.42
Human Site:
S457
Identified Species:
41.11
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
S457
Y
T
L
E
E
H
L
S
N
E
M
Q
A
K
E
Chimpanzee
Pan troglodytes
P61584
1003
117506
S216
T
A
V
R
L
R
K
S
H
T
E
M
S
K
S
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
S593
Y
T
L
E
E
H
L
S
S
E
I
Q
A
K
E
Dog
Lupus familis
XP_540083
1519
175559
S588
Y
T
L
E
E
H
L
S
T
E
I
Q
A
K
E
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
S457
Y
A
L
E
E
H
L
S
S
E
V
Q
A
K
E
Rat
Rattus norvegicus
Q62868
1379
159417
S448
Y
A
L
E
E
H
L
S
S
E
V
Q
A
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
V407
K
R
N
L
E
N
D
V
N
S
L
K
D
Q
L
Chicken
Gallus gallus
XP_419954
1438
166280
S507
S
K
L
E
E
Q
L
S
N
E
L
Q
A
K
D
Frog
Xenopus laevis
NP_001154860
1372
159002
H443
N
K
L
E
E
Q
L
H
N
E
M
Q
T
K
D
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
N443
H
C
L
E
E
Q
L
N
N
E
M
Q
A
K
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
P472
P
S
N
N
S
E
T
P
V
D
S
V
Q
L
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
L385
K
T
F
N
G
N
Q
L
P
F
I
G
F
T
Y
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
E413
H
S
L
E
K
Q
I
E
A
E
M
R
R
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
13.3
86.6
86.6
N.A.
80
80
N.A.
13.3
66.6
60
66.6
N.A.
0
N.A.
6.6
26.6
P-Site Similarity:
100
33.3
100
93.3
N.A.
93.3
93.3
N.A.
40
80
66.6
86.6
N.A.
20
N.A.
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
0
0
0
0
0
8
0
0
0
54
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
8
0
0
8
0
24
% D
% Glu:
0
0
0
70
70
8
0
8
0
70
8
0
0
0
39
% E
% Phe:
0
0
8
0
0
0
0
0
0
8
0
0
8
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% G
% His:
16
0
0
0
0
39
0
8
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
24
0
0
0
0
% I
% Lys:
16
16
0
0
8
0
8
0
0
0
0
8
0
70
16
% K
% Leu:
0
0
70
8
8
0
62
8
0
0
16
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
31
8
0
0
0
% M
% Asn:
8
0
16
16
0
16
0
8
39
0
0
0
0
8
0
% N
% Pro:
8
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
31
8
0
0
0
0
62
8
8
0
% Q
% Arg:
0
8
0
8
0
8
0
0
0
0
0
8
8
0
0
% R
% Ser:
8
16
0
0
8
0
0
54
24
8
8
0
8
0
8
% S
% Thr:
8
31
0
0
0
0
8
0
8
8
0
0
8
8
0
% T
% Val:
0
0
8
0
0
0
0
8
8
0
16
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
39
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _