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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
25.76
Human Site:
T677
Identified Species:
47.22
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
T677
R
Q
L
Q
E
R
F
T
D
L
E
K
E
K
S
Chimpanzee
Pan troglodytes
P61584
1003
117506
K403
D
L
K
Q
S
Q
Q
K
L
E
H
L
T
G
N
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
T813
R
Q
L
Q
E
R
F
T
D
L
E
K
E
K
S
Dog
Lupus familis
XP_540083
1519
175559
T808
R
Q
L
Q
E
R
L
T
D
L
E
K
E
K
N
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
T677
R
Q
L
Q
E
K
L
T
D
L
E
K
E
K
S
Rat
Rattus norvegicus
Q62868
1379
159417
T668
R
Q
L
Q
E
K
L
T
D
L
E
K
E
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
E597
A
D
K
N
K
I
Y
E
S
I
E
E
A
K
S
Chicken
Gallus gallus
XP_419954
1438
166280
T727
R
Q
L
Q
E
K
L
T
D
L
E
K
E
K
S
Frog
Xenopus laevis
NP_001154860
1372
159002
A663
Q
K
L
H
E
R
L
A
I
L
E
K
E
K
S
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
T663
R
Q
L
Q
E
K
L
T
D
M
E
K
E
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
K676
N
A
N
L
A
L
T
K
E
L
Q
Q
T
Q
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
E572
D
A
D
E
A
F
A
E
I
K
R
D
Y
E
L
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
E614
M
N
R
L
K
Q
G
E
S
R
S
I
A
T
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
6.6
100
86.6
N.A.
86.6
86.6
N.A.
20
86.6
60
80
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
20
100
93.3
N.A.
93.3
93.3
N.A.
46.6
93.3
73.3
93.3
N.A.
33.3
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
0
0
16
0
8
8
0
0
0
0
16
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
8
8
0
0
0
0
0
54
0
0
8
0
0
0
% D
% Glu:
0
0
0
8
62
0
0
24
8
8
70
8
62
8
8
% E
% Phe:
0
0
0
0
0
8
16
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
16
8
0
8
0
0
0
% I
% Lys:
0
8
16
0
16
31
0
16
0
8
0
62
0
70
0
% K
% Leu:
0
8
62
16
0
8
47
0
8
62
0
8
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% M
% Asn:
8
8
8
8
0
0
0
0
0
0
0
0
0
0
16
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
54
0
62
0
16
8
0
0
0
8
8
0
8
0
% Q
% Arg:
54
0
8
0
0
31
0
0
0
8
8
0
0
0
0
% R
% Ser:
0
0
0
0
8
0
0
0
16
0
8
0
0
0
62
% S
% Thr:
0
0
0
0
0
0
8
54
0
0
0
0
16
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _