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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIAA0652 All Species: 10.61
Human Site: S222 Identified Species: 21.21
UniProt: O75143 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75143 NP_001136145.1 517 56572 S222 F V D R P Y P S S S P M H P C
Chimpanzee Pan troglodytes A5A6N3 474 52050 E202 F M S T R Q F E R T P P I M G
Rhesus Macaque Macaca mulatta XP_001111885 517 56440 S222 F V D R P Y P S S S P M H P C
Dog Lupus familis XP_540752 642 70289 S222 F V D R P Y P S S S P M H P C
Cat Felis silvestris
Mouse Mus musculus Q91YI1 516 56422 P221 H F V D R P Y P S S S P M H P
Rat Rattus norvegicus XP_342466 516 56441 P221 H F V D R P Y P S S S P M H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517376 328 35088 G56 E R T P P I M G I I I D H F V
Chicken Gallus gallus XP_421116 549 59853 S254 S Q E V C T T S F S T S P P S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q7SYE0 503 54718 N222 F V E R P F T N M A H T H P C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VHR6 523 56908 A236 H F R P A T D A N T P G N Q Q
Honey Bee Apis mellifera XP_623782 410 45626 P138 L S V S R I T P A Y K L S R R
Nematode Worm Caenorhab. elegans P34379 443 49782 S171 R K I G E L V S K F G N I S L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91 99 78.9 N.A. 93.6 94.7 N.A. 57.4 87.4 N.A. 73.5 N.A. 25 33.2 22.6 N.A.
Protein Similarity: 100 91.3 99.4 79.1 N.A. 95.7 96.1 N.A. 59.5 90.5 N.A. 82.9 N.A. 40.5 50.4 43.5 N.A.
P-Site Identity: 100 13.3 100 100 N.A. 13.3 13.3 N.A. 13.3 20 N.A. 46.6 N.A. 6.6 0 6.6 N.A.
P-Site Similarity: 100 26.6 100 100 N.A. 13.3 13.3 N.A. 13.3 26.6 N.A. 73.3 N.A. 33.3 13.3 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 9 9 9 0 0 0 0 0 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 34 % C
% Asp: 0 0 25 17 0 0 9 0 0 0 0 9 0 0 0 % D
% Glu: 9 0 17 0 9 0 0 9 0 0 0 0 0 0 0 % E
% Phe: 42 25 0 0 0 9 9 0 9 9 0 0 0 9 0 % F
% Gly: 0 0 0 9 0 0 0 9 0 0 9 9 0 0 9 % G
% His: 25 0 0 0 0 0 0 0 0 0 9 0 42 17 0 % H
% Ile: 0 0 9 0 0 17 0 0 9 9 9 0 17 0 0 % I
% Lys: 0 9 0 0 0 0 0 0 9 0 9 0 0 0 0 % K
% Leu: 9 0 0 0 0 9 0 0 0 0 0 9 0 0 9 % L
% Met: 0 9 0 0 0 0 9 0 9 0 0 25 17 9 0 % M
% Asn: 0 0 0 0 0 0 0 9 9 0 0 9 9 0 0 % N
% Pro: 0 0 0 17 42 17 25 25 0 0 42 25 9 42 17 % P
% Gln: 0 9 0 0 0 9 0 0 0 0 0 0 0 9 9 % Q
% Arg: 9 9 9 34 34 0 0 0 9 0 0 0 0 9 9 % R
% Ser: 9 9 9 9 0 0 0 42 42 50 17 9 9 9 9 % S
% Thr: 0 0 9 9 0 17 25 0 0 17 9 9 0 0 0 % T
% Val: 0 34 25 9 0 0 9 0 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 25 17 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _