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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNF40 All Species: 22.42
Human Site: S649 Identified Species: 32.89
UniProt: O75150 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75150 NP_055586.1 1001 113678 S649 E E T K R K E S E L L K G L R
Chimpanzee Pan troglodytes Q2TLZ5 664 76145 I390 L V R L E Q D I K K L K A D L
Rhesus Macaque Macaca mulatta XP_001102375 1094 123413 S742 E E A K R K E S E L L K G L R
Dog Lupus familis XP_848895 1001 113606 S649 E E A K R K E S E L L K G L R
Cat Felis silvestris
Mouse Mus musculus Q3U319 1001 113949 S649 E E A K R K E S E L L K G L R
Rat Rattus norvegicus Q8CJB9 1002 113822 S650 E E A R R K E S E L L K G L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521737 913 103647 D593 K E M K L L L D M Y K S A P K
Chicken Gallus gallus Q5ZLS3 984 114789 A632 E D G R K K E A E V I K Q L K
Frog Xenopus laevis Q6DFL0 524 61335 M250 L K E R E D K M L L N K T I E
Zebra Danio Brachydanio rerio Q6NZW0 581 66777 N306 D K H A L I K N I E K L E A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VRP9 1044 119041 S668 K D V K A V E S E T V R D L K
Honey Bee Apis mellifera XP_625025 866 101052 S577 Q L K K I Q E S K R E E R K K
Nematode Worm Caenorhab. elegans P34537 837 97425 R563 N L Q K E V N R Q I A D K L S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RXD6 878 99700 A588 K A A N E A E A V S Q Q M L A
Baker's Yeast Sacchar. cerevisiae Q07457 700 80674 D426 K E Q W T K I D Q R S N D T K
Red Bread Mold Neurospora crassa Q7S304 707 80536 P433 E D V A K A A P T D D L S T L
Conservation
Percent
Protein Identity: 100 20.9 90 96.4 N.A. 92.5 92.5 N.A. 70.5 58.9 20.6 20.3 N.A. 43 47.5 25 N.A.
Protein Similarity: 100 36.9 90.4 97.5 N.A. 95.1 95.2 N.A. 76.5 74 34 35.1 N.A. 60.5 62.2 46.3 N.A.
P-Site Identity: 100 13.3 93.3 93.3 N.A. 93.3 86.6 N.A. 13.3 40 13.3 0 N.A. 33.3 20 13.3 N.A.
P-Site Similarity: 100 33.3 93.3 93.3 N.A. 93.3 93.3 N.A. 26.6 86.6 40 26.6 N.A. 66.6 53.3 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.6 21.2 23.2
Protein Similarity: N.A. N.A. N.A. 44.2 39.6 40.4
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 32 13 7 13 7 13 0 0 7 0 13 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 19 0 0 0 7 7 13 0 7 7 7 13 7 0 % D
% Glu: 44 44 7 0 25 0 57 0 44 7 7 7 7 0 13 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 0 0 0 0 0 0 0 0 0 32 0 0 % G
% His: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 7 7 7 7 7 7 0 0 7 0 % I
% Lys: 25 13 7 50 13 44 13 0 13 7 13 50 7 7 32 % K
% Leu: 13 13 0 7 13 7 7 0 7 38 38 13 0 57 13 % L
% Met: 0 0 7 0 0 0 0 7 7 0 0 0 7 0 0 % M
% Asn: 7 0 0 7 0 0 7 7 0 0 7 7 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 7 0 0 0 0 0 7 0 % P
% Gln: 7 0 13 0 0 13 0 0 13 0 7 7 7 0 0 % Q
% Arg: 0 0 7 19 32 0 0 7 0 13 0 7 7 0 32 % R
% Ser: 0 0 0 0 0 0 0 44 0 7 7 7 7 0 7 % S
% Thr: 0 0 7 0 7 0 0 0 7 7 0 0 7 13 0 % T
% Val: 0 7 13 0 0 13 0 0 7 7 7 0 0 0 0 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _