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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIN3B All Species: 20.91
Human Site: S241 Identified Species: 38.33
UniProt: O75182 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75182 NP_056075.1 1162 133066 S241 F L P E A K R S L F T G N G P
Chimpanzee Pan troglodytes XP_512485 1159 132821 S238 F L P E A K R S L F T G N G P
Rhesus Macaque Macaca mulatta XP_001103619 1210 138821 E275 I L H T Y Q K E Q R N A K E A
Dog Lupus familis XP_852728 1090 125608 K233 K N L E H S K K R S R P S L L
Cat Felis silvestris
Mouse Mus musculus Q62141 1098 126387 F235 P E A K R S L F T G N G S C E
Rat Rattus norvegicus NP_001102231 1129 127784 T237 P S A Q S A P T P A Q P A P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511618 1116 128787 S235 F L P E A K R S L F T G N G P
Chicken Gallus gallus XP_418257 1273 146269 S392 F L P E A K R S L F T G N G P
Frog Xenopus laevis NP_001090601 1125 130319 S243 F L P E A K R S L F T G N G A
Zebra Danio Brachydanio rerio NP_001038410 1196 136639 S247 E Q L E V K E S R G R S T G G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188916 1290 146297 S380 S G G T Y Q P S L S E T Q V F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O48686 1353 153834 R257 E N E H R D A R D F E P H S K
Baker's Yeast Sacchar. cerevisiae P22579 1536 174821 Q487 Q Q V Q H A Q Q H A Q Q Q H E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 51.9 89.9 N.A. 87.6 50.9 N.A. 85.8 77.4 71.4 63.9 N.A. N.A. N.A. N.A. 44.5
Protein Similarity: 100 99.5 66.7 91.9 N.A. 91.3 64 N.A. 91 82.4 82.1 76 N.A. N.A. N.A. N.A. 59
P-Site Identity: 100 100 6.6 6.6 N.A. 6.6 0 N.A. 100 100 93.3 26.6 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 20 20 N.A. 20 20 N.A. 100 100 93.3 26.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 23.2 24.2 N.A.
Protein Similarity: N.A. N.A. N.A. 38.8 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 39 16 8 0 0 16 0 8 8 0 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % D
% Glu: 16 8 8 54 0 0 8 8 0 0 16 0 0 8 16 % E
% Phe: 39 0 0 0 0 0 0 8 0 47 0 0 0 0 8 % F
% Gly: 0 8 8 0 0 0 0 0 0 16 0 47 0 47 8 % G
% His: 0 0 8 8 16 0 0 0 8 0 0 0 8 8 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 8 0 47 16 8 0 0 0 0 8 0 8 % K
% Leu: 0 47 16 0 0 0 8 0 47 0 0 0 0 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 16 0 0 0 0 0 0 0 0 16 0 39 0 0 % N
% Pro: 16 0 39 0 0 0 16 0 8 0 0 24 0 8 31 % P
% Gln: 8 16 0 16 0 16 8 8 8 0 16 8 16 0 8 % Q
% Arg: 0 0 0 0 16 0 39 8 16 8 16 0 0 0 0 % R
% Ser: 8 8 0 0 8 16 0 54 0 16 0 8 16 8 0 % S
% Thr: 0 0 0 16 0 0 0 8 8 0 39 8 8 0 0 % T
% Val: 0 0 8 0 8 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _