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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIN3B
All Species:
16.67
Human Site:
S270
Identified Species:
30.56
UniProt:
O75182
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75182
NP_056075.1
1162
133066
S270
P
E
H
S
R
K
R
S
R
P
S
L
L
R
P
Chimpanzee
Pan troglodytes
XP_512485
1159
132821
S267
P
E
H
S
R
K
R
S
R
P
S
L
L
R
P
Rhesus Macaque
Macaca mulatta
XP_001103619
1210
138821
K304
A
Q
V
A
R
L
F
K
N
Q
E
D
L
L
S
Dog
Lupus familis
XP_852728
1090
125608
A262
G
T
K
D
L
S
I
A
A
V
G
K
Y
G
T
Cat
Felis silvestris
Mouse
Mus musculus
Q62141
1098
126387
S264
N
K
K
R
S
R
P
S
L
L
R
P
V
S
A
Rat
Rattus norvegicus
NP_001102231
1129
127784
T266
H
T
P
A
S
Q
Q
T
P
P
L
P
P
Y
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511618
1116
128787
S264
M
D
H
T
K
K
R
S
R
P
L
L
L
R
P
Chicken
Gallus gallus
XP_418257
1273
146269
S421
L
E
H
S
K
K
R
S
R
P
L
L
L
R
P
Frog
Xenopus laevis
NP_001090601
1125
130319
R272
E
Q
S
R
K
R
S
R
P
L
L
L
R
S
M
Zebra Danio
Brachydanio rerio
NP_001038410
1196
136639
A276
K
G
Q
E
D
L
L
A
E
F
G
Q
F
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188916
1290
146297
P409
K
E
F
G
H
F
L
P
D
A
N
G
A
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O48686
1353
153834
S286
G
D
D
P
A
E
I
S
N
Q
S
K
L
S
G
Baker's Yeast
Sacchar. cerevisiae
P22579
1536
174821
Q516
A
Q
V
E
Q
Q
K
Q
Q
Q
Q
F
L
Y
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
51.9
89.9
N.A.
87.6
50.9
N.A.
85.8
77.4
71.4
63.9
N.A.
N.A.
N.A.
N.A.
44.5
Protein Similarity:
100
99.5
66.7
91.9
N.A.
91.3
64
N.A.
91
82.4
82.1
76
N.A.
N.A.
N.A.
N.A.
59
P-Site Identity:
100
100
13.3
0
N.A.
6.6
6.6
N.A.
66.6
80
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
26.6
6.6
N.A.
26.6
33.3
N.A.
86.6
86.6
26.6
13.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.2
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
16
8
0
0
16
8
8
0
0
8
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
8
8
8
0
0
0
8
0
0
8
0
0
0
% D
% Glu:
8
31
0
16
0
8
0
0
8
0
8
0
0
0
0
% E
% Phe:
0
0
8
0
0
8
8
0
0
8
0
8
8
0
0
% F
% Gly:
16
8
0
8
0
0
0
0
0
0
16
8
0
8
16
% G
% His:
8
0
31
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% I
% Lys:
16
8
16
0
24
31
8
8
0
0
0
16
0
0
0
% K
% Leu:
8
0
0
0
8
16
16
0
8
16
31
39
54
16
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
0
0
0
0
0
0
16
0
8
0
0
0
0
% N
% Pro:
16
0
8
8
0
0
8
8
16
39
0
16
8
0
47
% P
% Gln:
0
24
8
0
8
16
8
8
8
24
8
8
0
0
0
% Q
% Arg:
0
0
0
16
24
16
31
8
31
0
8
0
8
31
0
% R
% Ser:
0
0
8
24
16
8
8
47
0
0
24
0
0
24
8
% S
% Thr:
0
16
0
8
0
0
0
8
0
0
0
0
0
0
8
% T
% Val:
0
0
16
0
0
0
0
0
0
8
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _