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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIN3B All Species: 9.09
Human Site: S378 Identified Species: 16.67
UniProt: O75182 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75182 NP_056075.1 1162 133066 S378 L S F A P P M S D R S G D G I
Chimpanzee Pan troglodytes XP_512485 1159 132821 S375 L S F A P P M S D R S G D G I
Rhesus Macaque Macaca mulatta XP_001103619 1210 138821 L440 S R A E L V Q L V S P F L G K
Dog Lupus familis XP_852728 1090 125608 L369 I G S S Y R A L P K T Y Q Q P
Cat Felis silvestris
Mouse Mus musculus Q62141 1098 126387 S372 A P P M S D R S G D G I S R E
Rat Rattus norvegicus NP_001102231 1129 127784 Q378 D L L S E F G Q F L P D A N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511618 1116 128787 N372 L S F A P P M N D R S A D G I
Chicken Gallus gallus XP_418257 1273 146269 S529 L S F A S P L S D R S G D G M
Frog Xenopus laevis NP_001090601 1125 130319 N379 S F A S P V T N D R S N E G I
Zebra Danio Brachydanio rerio NP_001038410 1196 136639 L390 S G A E L L Q L V T P F L G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188916 1290 146297 N530 A E L V Q L V N P F L G K F P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O48686 1353 153834 Q402 Q G E G K Y P Q P S L D N D R
Baker's Yeast Sacchar. cerevisiae P22579 1536 174821 I696 L N L Y S Q D I L D L D D L V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 51.9 89.9 N.A. 87.6 50.9 N.A. 85.8 77.4 71.4 63.9 N.A. N.A. N.A. N.A. 44.5
Protein Similarity: 100 99.5 66.7 91.9 N.A. 91.3 64 N.A. 91 82.4 82.1 76 N.A. N.A. N.A. N.A. 59
P-Site Identity: 100 100 6.6 0 N.A. 6.6 0 N.A. 86.6 80 40 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 6.6 26.6 N.A. 6.6 6.6 N.A. 93.3 93.3 60 6.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 23.2 24.2 N.A.
Protein Similarity: N.A. N.A. N.A. 38.8 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 24 31 0 0 8 0 0 0 0 8 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 8 8 0 39 16 0 24 39 8 0 % D
% Glu: 0 8 8 16 8 0 0 0 0 0 0 0 8 0 8 % E
% Phe: 0 8 31 0 0 8 0 0 8 8 0 16 0 8 0 % F
% Gly: 0 24 0 8 0 0 8 0 8 0 8 31 0 54 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 0 8 0 0 0 8 0 0 31 % I
% Lys: 0 0 0 0 8 0 0 0 0 8 0 0 8 0 16 % K
% Leu: 39 8 24 0 16 16 8 24 8 8 24 0 16 8 0 % L
% Met: 0 0 0 8 0 0 24 0 0 0 0 0 0 0 8 % M
% Asn: 0 8 0 0 0 0 0 24 0 0 0 8 8 8 0 % N
% Pro: 0 8 8 0 31 31 8 0 24 0 24 0 0 0 16 % P
% Gln: 8 0 0 0 8 8 16 16 0 0 0 0 8 8 0 % Q
% Arg: 0 8 0 0 0 8 8 0 0 39 0 0 0 8 8 % R
% Ser: 24 31 8 24 24 0 0 31 0 16 39 0 8 0 8 % S
% Thr: 0 0 0 0 0 0 8 0 0 8 8 0 0 0 0 % T
% Val: 0 0 0 8 0 16 8 0 16 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 8 8 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _