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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRP5
All Species:
19.09
Human Site:
Y1573
Identified Species:
38.18
UniProt:
O75197
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75197
NP_002326.2
1615
179145
Y1573
L
N
S
D
S
D
P
Y
P
P
P
P
T
P
H
Chimpanzee
Pan troglodytes
XP_508605
1701
188045
Y1659
L
N
S
D
S
D
P
Y
P
P
P
P
T
P
H
Rhesus Macaque
Macaca mulatta
XP_001117791
1209
134638
S1168
K
V
R
L
L
L
V
S
R
L
L
P
L
S
L
Dog
Lupus familis
XP_866872
1612
180302
Y1561
G
Y
T
S
D
L
N
Y
D
S
E
P
V
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q91VN0
1614
178879
Y1572
L
N
S
D
S
D
P
Y
P
P
P
P
T
P
H
Rat
Rattus norvegicus
Q9QYP1
1905
211861
A1785
I
E
A
A
P
K
P
A
M
Y
N
Q
L
C
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508455
1480
165692
L1427
S
K
G
Y
A
S
D
L
N
Y
D
S
E
P
V
Chicken
Gallus gallus
NP_001012915
1616
180864
Y1574
L
N
S
D
S
D
P
Y
P
P
P
P
T
P
R
Frog
Xenopus laevis
NP_001079163
1605
179641
Y1563
L
N
S
D
S
D
P
Y
P
P
P
P
T
P
R
Zebra Danio
Brachydanio rerio
XP_696943
1405
157848
P1364
N
S
D
S
D
P
Y
P
P
P
P
T
P
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P98163
1984
219502
G1705
A
V
Q
C
A
L
Y
G
S
R
I
C
H
K
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202408
1322
148003
P1281
Y
D
S
E
P
Y
P
P
P
P
T
P
H
S
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
61.5
70
N.A.
93.9
28.4
N.A.
63.9
87.8
80.1
66.5
N.A.
20.3
N.A.
N.A.
41.6
Protein Similarity:
100
94.4
62.9
83.2
N.A.
96.4
43.3
N.A.
76.1
94
88.7
75.6
N.A.
34.8
N.A.
N.A.
54.9
P-Site Identity:
100
100
6.6
20
N.A.
100
6.6
N.A.
6.6
93.3
93.3
20
N.A.
0
N.A.
N.A.
33.3
P-Site Similarity:
100
100
6.6
26.6
N.A.
100
26.6
N.A.
13.3
93.3
93.3
26.6
N.A.
6.6
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
9
17
0
0
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
9
0
9
0
% C
% Asp:
0
9
9
42
17
42
9
0
9
0
9
0
0
0
0
% D
% Glu:
0
9
0
9
0
0
0
0
0
0
9
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
9
0
0
0
0
9
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
25
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% I
% Lys:
9
9
0
0
0
9
0
0
0
0
0
0
0
9
0
% K
% Leu:
42
0
0
9
9
25
0
9
0
9
9
0
17
0
9
% L
% Met:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
9
42
0
0
0
0
9
0
9
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
17
9
59
17
59
59
50
67
9
59
9
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
9
0
0
9
% Q
% Arg:
0
0
9
0
0
0
0
0
9
9
0
0
0
9
17
% R
% Ser:
9
9
50
17
42
9
0
9
9
9
0
9
0
17
9
% S
% Thr:
0
0
9
0
0
0
0
0
0
0
9
9
42
0
0
% T
% Val:
0
17
0
0
0
0
9
0
0
0
0
0
9
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
9
0
9
0
9
17
50
0
17
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _