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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZNF259
All Species:
20.3
Human Site:
Y222
Identified Species:
40.61
UniProt:
O75312
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75312
NP_003895.1
459
50925
Y222
D
A
L
V
I
T
H
Y
N
R
T
R
Q
Q
E
Chimpanzee
Pan troglodytes
XP_001152978
459
50861
Y222
D
A
L
V
I
T
Y
Y
N
R
T
R
Q
Q
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850312
460
51120
Y222
L
A
L
I
I
T
H
Y
N
R
T
L
Q
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q62384
459
50696
Y222
N
A
L
V
I
T
Y
Y
D
R
T
P
Q
Q
A
Rat
Rattus norvegicus
NP_001131118
459
50836
Y222
S
A
L
V
I
T
Y
Y
D
R
T
P
Q
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026668
231
25792
N28
R
N
E
V
L
Q
F
N
T
N
C
P
E
C
N
Frog
Xenopus laevis
NP_001121222
446
49990
S221
R
L
L
G
L
E
N
S
S
T
S
L
K
Q
E
Zebra Danio
Brachydanio rerio
NP_998273
441
49235
E219
A
A
L
G
I
E
V
E
E
E
Q
A
D
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572532
457
51282
Y227
Q
N
E
Q
L
G
L
Y
E
Q
N
H
E
E
Q
Honey Bee
Apis mellifera
XP_394704
445
50434
E222
H
I
L
G
I
Y
T
E
N
S
E
D
T
L
L
Nematode Worm
Caenorhab. elegans
O16999
455
50911
A226
E
E
V
E
P
S
A
A
A
P
E
F
K
S
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53303
486
55054
D241
Q
V
G
I
I
T
R
D
Q
L
E
Q
R
R
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
89.7
N.A.
90.4
89.1
N.A.
N.A.
40.5
68.6
68.6
N.A.
48.5
51.4
41.1
N.A.
Protein Similarity:
100
99.7
N.A.
94.3
N.A.
94.3
92.8
N.A.
N.A.
45
82.5
81.2
N.A.
67.3
69.2
61.4
N.A.
P-Site Identity:
100
93.3
N.A.
80
N.A.
66.6
66.6
N.A.
N.A.
6.6
20
20
N.A.
6.6
20
0
N.A.
P-Site Similarity:
100
100
N.A.
86.6
N.A.
86.6
80
N.A.
N.A.
20
53.3
26.6
N.A.
40
20
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
50
0
0
0
0
9
9
9
0
0
9
0
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
9
0
% C
% Asp:
17
0
0
0
0
0
0
9
17
0
0
9
9
0
0
% D
% Glu:
9
9
17
9
0
17
0
17
17
9
25
0
17
17
34
% E
% Phe:
0
0
0
0
0
0
9
0
0
0
0
9
0
0
0
% F
% Gly:
0
0
9
25
0
9
0
0
0
0
0
0
0
0
0
% G
% His:
9
0
0
0
0
0
17
0
0
0
0
9
0
0
0
% H
% Ile:
0
9
0
17
67
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
0
% K
% Leu:
9
9
67
0
25
0
9
0
0
9
0
17
0
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
17
0
0
0
0
9
9
34
9
9
0
0
0
9
% N
% Pro:
0
0
0
0
9
0
0
0
0
9
0
25
0
0
0
% P
% Gln:
17
0
0
9
0
9
0
0
9
9
9
9
42
50
17
% Q
% Arg:
17
0
0
0
0
0
9
0
0
42
0
17
9
9
0
% R
% Ser:
9
0
0
0
0
9
0
9
9
9
9
0
0
9
9
% S
% Thr:
0
0
0
0
0
50
9
0
9
9
42
0
9
0
0
% T
% Val:
0
9
9
42
0
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
25
50
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _