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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMMR All Species: 25.76
Human Site: S128 Identified Species: 43.59
UniProt: O75330 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75330 NP_036616.2 724 84100 S128 A A L R E K T S L S A N N A T
Chimpanzee Pan troglodytes XP_001145921 725 84298 S129 A A F R E K T S L S A N N A T
Rhesus Macaque Macaca mulatta XP_001088518 714 82407 S129 A A L R E K T S L S A N N A T
Dog Lupus familis XP_854651 712 82189 S129 A A V R E K T S L S A S N A S
Cat Felis silvestris
Mouse Mus musculus Q00547 794 91781 S129 A A V R E K T S L S A S N A S
Rat Rattus norvegicus P97779 498 57840 E34 S C A S D Q V E K Y K L D I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510078 1224 143817 S232 A A V R E K T S L S A N I A S
Chicken Gallus gallus XP_414495 735 84777 S139 A A V Q E K T S L L A N V A C
Frog Xenopus laevis Q91785 1388 159123 F556 I A E L E K A F L E V S V S E
Zebra Danio Brachydanio rerio NP_955874 903 104691 G137 V A V R E K T G L A A N V I S
Tiger Blowfish Takifugu rubipres NP_001011731 834 97660 E198 T V R Q Q E G E L A R L R E V
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 A491 G A L Q E E I A K L Q E K M T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785252 773 89752 K125 E E E T K R R K D A Q E K V E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32380 944 111763 G224 R K V D D H S G C I E E R E Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 94.8 85 N.A. 68.8 50.2 N.A. 36.3 49.7 21.2 33.5 26.5 22.5 N.A. N.A. 24.3
Protein Similarity: 100 98.7 96.4 91.5 N.A. 78 57.5 N.A. 47.2 68.5 35.7 50.9 48.8 32.3 N.A. N.A. 46.9
P-Site Identity: 100 93.3 100 80 N.A. 80 0 N.A. 80 66.6 26.6 53.3 6.6 26.6 N.A. N.A. 0
P-Site Similarity: 100 93.3 100 100 N.A. 100 26.6 N.A. 93.3 80 40 73.3 33.3 46.6 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 50 72 8 0 0 0 8 8 0 22 58 0 0 50 8 % A
% Cys: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 8 % C
% Asp: 0 0 0 8 15 0 0 0 8 0 0 0 8 0 0 % D
% Glu: 8 8 15 0 72 15 0 15 0 8 8 22 0 15 15 % E
% Phe: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 0 8 15 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 8 0 0 8 0 0 8 15 0 % I
% Lys: 0 8 0 0 8 65 0 8 15 0 8 0 15 0 0 % K
% Leu: 0 0 22 8 0 0 0 0 72 15 0 15 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 43 36 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 22 8 8 0 0 0 0 15 0 0 0 8 % Q
% Arg: 8 0 8 50 0 8 8 0 0 0 8 0 15 0 0 % R
% Ser: 8 0 0 8 0 0 8 50 0 43 0 22 0 8 29 % S
% Thr: 8 0 0 8 0 0 58 0 0 0 0 0 0 0 29 % T
% Val: 8 8 43 0 0 0 8 0 0 0 8 0 22 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _