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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMMR All Species: 20.3
Human Site: S656 Identified Species: 34.36
UniProt: O75330 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75330 NP_036616.2 724 84100 S656 S Q L K S E V S K L R C Q L A
Chimpanzee Pan troglodytes XP_001145921 725 84298 S657 S Q L K S E V S K L R C Q L A
Rhesus Macaque Macaca mulatta XP_001088518 714 82407 S650 V K L K D E N S Q L K S E V S
Dog Lupus familis XP_854651 712 82189 E648 H V V K L K D E N S Q L K S E
Cat Felis silvestris
Mouse Mus musculus Q00547 794 91781 V726 K Q K I K H V V K L K D E N S
Rat Rattus norvegicus P97779 498 57840 S434 V K L K D E N S Q L K S E V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510078 1224 143817 S1070 G Q L K S E V S K L R S Q L V
Chicken Gallus gallus XP_414495 735 84777 T671 M K L K E D N T H L Q Q D I S
Frog Xenopus laevis Q91785 1388 159123 L1203 C E T E N M R L E I Q N L Q G
Zebra Danio Brachydanio rerio NP_955874 903 104691 V836 R Q K I K H M V K L K E E N L
Tiger Blowfish Takifugu rubipres NP_001011731 834 97660 A748 N K L S D A Y A R L L G H Q N
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 S1437 R T L Q E E T S K L A E Q L S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785252 773 89752 A693 N K L S N D Y A K L L G H Q N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32380 944 111763 N833 K V I N D Y L N K V L A L G T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 94.8 85 N.A. 68.8 50.2 N.A. 36.3 49.7 21.2 33.5 26.5 22.5 N.A. N.A. 24.3
Protein Similarity: 100 98.7 96.4 91.5 N.A. 78 57.5 N.A. 47.2 68.5 35.7 50.9 48.8 32.3 N.A. N.A. 46.9
P-Site Identity: 100 100 33.3 6.6 N.A. 26.6 33.3 N.A. 80 20 0 20 13.3 46.6 N.A. N.A. 20
P-Site Similarity: 100 100 73.3 33.3 N.A. 46.6 73.3 N.A. 80 60 40 40 40 60 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 15 0 0 8 8 0 0 15 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % C
% Asp: 0 0 0 0 29 15 8 0 0 0 0 8 8 0 0 % D
% Glu: 0 8 0 8 15 43 0 8 8 0 0 15 29 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 15 0 8 8 % G
% His: 8 0 0 0 0 15 0 0 8 0 0 0 15 0 0 % H
% Ile: 0 0 8 15 0 0 0 0 0 8 0 0 0 8 0 % I
% Lys: 15 36 15 50 15 8 0 0 58 0 29 0 8 0 0 % K
% Leu: 0 0 65 0 8 0 8 8 0 79 22 8 15 29 8 % L
% Met: 8 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % M
% Asn: 15 0 0 8 15 0 22 8 8 0 0 8 0 15 15 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 36 0 8 0 0 0 0 15 0 22 8 29 22 0 % Q
% Arg: 15 0 0 0 0 0 8 0 8 0 22 0 0 0 0 % R
% Ser: 15 0 0 15 22 0 0 43 0 8 0 22 0 8 36 % S
% Thr: 0 8 8 0 0 0 8 8 0 0 0 0 0 0 8 % T
% Val: 15 15 8 0 0 0 29 15 0 8 0 0 0 15 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 15 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _