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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMMR All Species: 14.55
Human Site: S74 Identified Species: 24.62
UniProt: O75330 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75330 NP_036616.2 724 84100 S74 R K V K S S E S K E S Q K N D
Chimpanzee Pan troglodytes XP_001145921 725 84298 S74 R K V K S S E S K K E S Q K N
Rhesus Macaque Macaca mulatta XP_001088518 714 82407 S74 R K V K S S E S K K E S Q K N
Dog Lupus familis XP_854651 712 82189 L74 R K V K T L G L K K E S Q K N
Cat Felis silvestris
Mouse Mus musculus Q00547 794 91781 S74 K K A K K S V S K K D S Q K N
Rat Rattus norvegicus P97779 498 57840
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510078 1224 143817 S174 R K H K I L E S Q K K A Q K D
Chicken Gallus gallus XP_414495 735 84777 L74 R L A S L G S L P V S G S L K
Frog Xenopus laevis Q91785 1388 159123 A407 M P G D I S V A R V P S V G D
Zebra Danio Brachydanio rerio NP_955874 903 104691 A74 T M S V D G L A D A L S S K K
Tiger Blowfish Takifugu rubipres NP_001011731 834 97660 Y139 K E E D A Q I Y Q Q E L Q A L
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 A398 R E D A Q N Q A L Q L Q K N I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785252 773 89752 A85 M G E N L S H A E S T I S S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32380 944 111763 F77 L F S E A S Q F D D S F P E I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 94.8 85 N.A. 68.8 50.2 N.A. 36.3 49.7 21.2 33.5 26.5 22.5 N.A. N.A. 24.3
Protein Similarity: 100 98.7 96.4 91.5 N.A. 78 57.5 N.A. 47.2 68.5 35.7 50.9 48.8 32.3 N.A. N.A. 46.9
P-Site Identity: 100 60 60 33.3 N.A. 33.3 0 N.A. 40 13.3 13.3 0 0 26.6 N.A. N.A. 6.6
P-Site Similarity: 100 80 80 60 N.A. 60 0 N.A. 60 13.3 26.6 6.6 40 60 N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 8 15 0 0 29 0 8 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 15 8 0 0 0 15 8 8 0 0 0 22 % D
% Glu: 0 15 15 8 0 0 29 0 8 8 29 0 0 8 0 % E
% Phe: 0 8 0 0 0 0 0 8 0 0 0 8 0 0 0 % F
% Gly: 0 8 8 0 0 15 8 0 0 0 0 8 0 8 0 % G
% His: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 15 0 8 0 0 0 0 8 0 0 15 % I
% Lys: 15 43 0 43 8 0 0 0 36 36 8 0 15 43 15 % K
% Leu: 8 8 0 0 15 15 8 15 8 0 15 8 0 8 15 % L
% Met: 15 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 0 0 0 0 0 0 0 15 29 % N
% Pro: 0 8 0 0 0 0 0 0 8 0 8 0 8 0 0 % P
% Gln: 0 0 0 0 8 8 15 0 15 15 0 15 43 0 0 % Q
% Arg: 50 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % R
% Ser: 0 0 15 8 22 50 8 36 0 8 22 43 22 8 0 % S
% Thr: 8 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % T
% Val: 0 0 29 8 0 0 15 0 0 15 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _