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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMMR All Species: 29.09
Human Site: T230 Identified Species: 49.23
UniProt: O75330 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75330 NP_036616.2 724 84100 T230 K I D E K S E T E K L L E Y I
Chimpanzee Pan troglodytes XP_001145921 725 84298 T231 K I D E K S E T E K L L E Y I
Rhesus Macaque Macaca mulatta XP_001088518 714 82407 T231 K I D E K S E T E K L L E Y I
Dog Lupus familis XP_854651 712 82189 T231 K T D E K S E T E K L L E Y I
Cat Felis silvestris
Mouse Mus musculus Q00547 794 91781 T231 K I D E K C E T E K L L E Y I
Rat Rattus norvegicus P97779 498 57840 Q132 L Q S Q S L L Q Q E K E L S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510078 1224 143817 T334 I V E E K S D T G R L L D Y I
Chicken Gallus gallus XP_414495 735 84777 T241 K V E D K S D T E K L L E Y I
Frog Xenopus laevis Q91785 1388 159123 N746 L D E E E G K N I R L Q Q Q V
Zebra Danio Brachydanio rerio NP_955874 903 104691 I275 L D S A N E E I Q D L R I K L
Tiger Blowfish Takifugu rubipres NP_001011731 834 97660 V345 E Q K K Q E V V E K S Q E E V
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 K694 A A K T L N D K E Q L E K Q I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785252 773 89752 L234 T T E D K E D L E M I G D R L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32380 944 111763 S327 L K Q K Q N E S K R L K D E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 94.8 85 N.A. 68.8 50.2 N.A. 36.3 49.7 21.2 33.5 26.5 22.5 N.A. N.A. 24.3
Protein Similarity: 100 98.7 96.4 91.5 N.A. 78 57.5 N.A. 47.2 68.5 35.7 50.9 48.8 32.3 N.A. N.A. 46.9
P-Site Identity: 100 100 100 93.3 N.A. 93.3 0 N.A. 53.3 73.3 13.3 13.3 20 20 N.A. N.A. 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 20 N.A. 86.6 100 53.3 26.6 46.6 46.6 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 0 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 15 36 15 0 0 29 0 0 8 0 0 22 0 0 % D
% Glu: 8 0 29 50 8 22 50 0 65 8 0 15 50 15 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 0 8 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 29 0 0 0 0 0 8 8 0 8 0 8 0 58 % I
% Lys: 43 8 15 15 58 0 8 8 8 50 8 8 8 8 0 % K
% Leu: 29 0 0 0 8 8 8 8 0 0 79 50 8 0 22 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 15 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 15 8 8 15 0 0 8 15 8 0 15 8 15 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 22 0 8 0 8 0 % R
% Ser: 0 0 15 0 8 43 0 8 0 0 8 0 0 8 0 % S
% Thr: 8 15 0 8 0 0 0 50 0 0 0 0 0 0 0 % T
% Val: 0 15 0 0 0 0 8 8 0 0 0 0 0 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 50 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _