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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALOX12B All Species: 18.18
Human Site: Y497 Identified Species: 40
UniProt: O75342 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75342 NP_001130.1 701 80356 Y497 V Q D L P G Y Y Y R D D S L A
Chimpanzee Pan troglodytes XP_511864 701 80411 Y497 V Q D L P G Y Y Y R D D S L A
Rhesus Macaque Macaca mulatta XP_001111929 711 80558 H507 V L A I P N Y H Y R D D G L K
Dog Lupus familis XP_546604 699 80232 Y495 V Q D L P G Y Y Y R D D S L A
Cat Felis silvestris
Mouse Mus musculus O70582 701 80559 Y497 V Q D L P G Y Y F R D D S L A
Rat Rattus norvegicus Q2KMM4 701 80722 Y497 V Q D L P G Y Y F R D D S L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517706 444 51126 M251 G S Q L V I I M A K G N I Y L
Chicken Gallus gallus XP_423676 651 74206 E457 D D G M S L W E A I K R F V S
Frog Xenopus laevis NP_001089265 670 75862 F466 V D S V P N Y F Y R E D G M R
Zebra Danio Brachydanio rerio NP_955912 670 76988 V466 V T K V K G Y V Y R D Y S L M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LNR3 919 103708 P689 K L L I E D Y P Y A N D G L L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 54.2 88.1 N.A. 86 86.5 N.A. 44 47.5 44.9 40.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.8 72.2 96 N.A. 94 94.1 N.A. 51 64.7 64.3 59 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 53.3 100 N.A. 93.3 93.3 N.A. 6.6 0 40 53.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 66.6 100 N.A. 100 100 N.A. 20 26.6 66.6 60 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 19 10 0 0 0 0 46 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 19 46 0 0 10 0 0 0 0 64 73 0 0 0 % D
% Glu: 0 0 0 0 10 0 0 10 0 0 10 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 10 19 0 0 0 10 0 0 % F
% Gly: 10 0 10 0 0 55 0 0 0 0 10 0 28 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 19 0 10 10 0 0 10 0 0 10 0 0 % I
% Lys: 10 0 10 0 10 0 0 0 0 10 10 0 0 0 10 % K
% Leu: 0 19 10 55 0 10 0 0 0 0 0 0 0 73 19 % L
% Met: 0 0 0 10 0 0 0 10 0 0 0 0 0 10 10 % M
% Asn: 0 0 0 0 0 19 0 0 0 0 10 10 0 0 0 % N
% Pro: 0 0 0 0 64 0 0 10 0 0 0 0 0 0 0 % P
% Gln: 0 46 10 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 73 0 10 0 0 10 % R
% Ser: 0 10 10 0 10 0 0 0 0 0 0 0 55 0 10 % S
% Thr: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 73 0 0 19 10 0 0 10 0 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 82 46 64 0 0 10 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _