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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1B2
All Species:
27.58
Human Site:
Y56
Identified Species:
60.67
UniProt:
O75343
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75343
NULL
617
70368
Y56
G
K
M
F
L
H
Y
Y
S
D
R
S
G
L
C
Chimpanzee
Pan troglodytes
XP_509785
694
79553
Y133
G
K
M
F
L
H
Y
Y
S
D
R
S
G
L
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542553
919
101284
Y230
G
R
M
L
L
H
Y
Y
S
D
R
S
G
L
C
Cat
Felis silvestris
Mouse
Mus musculus
O54865
620
70579
S92
T
I
L
R
V
L
G
S
N
V
R
E
F
L
Q
Rat
Rattus norvegicus
P22717
682
76178
Y73
G
A
M
L
L
H
Y
Y
S
D
R
H
G
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513546
999
112853
Y389
G
I
I
L
L
H
Y
Y
S
D
R
S
G
L
C
Chicken
Gallus gallus
XP_426684
933
104531
Y291
G
S
M
H
L
H
Y
Y
S
D
R
R
G
L
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_685297
806
92435
Y182
G
R
I
L
L
H
Y
Y
S
D
R
K
G
L
Y
Tiger Blowfish
Takifugu rubipres
NP_001027728
617
70218
S92
T
I
L
R
V
L
G
S
N
V
R
E
F
L
Q
Fruit Fly
Dros. melanogaster
Q8INF0
947
105028
Y80
F
V
G
F
V
G
Q
Y
G
Y
D
R
V
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02298
688
78384
E64
N
V
I
G
I
P
I
E
E
I
W
E
A
Y
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.7
N.A.
55.2
N.A.
31.1
72.7
N.A.
48.3
45
N.A.
53.2
30.9
22.8
N.A.
32.2
N.A.
Protein Similarity:
100
88.3
N.A.
60.9
N.A.
49.5
80.9
N.A.
55.2
53.5
N.A.
64.6
50.5
38.6
N.A.
51.1
N.A.
P-Site Identity:
100
100
N.A.
86.6
N.A.
13.3
80
N.A.
80
73.3
N.A.
66.6
13.3
20
N.A.
0
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
33.3
80
N.A.
86.6
73.3
N.A.
80
33.3
26.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
46
% C
% Asp:
0
0
0
0
0
0
0
0
0
64
10
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
10
0
0
28
0
0
0
% E
% Phe:
10
0
0
28
0
0
0
0
0
0
0
0
19
0
0
% F
% Gly:
64
0
10
10
0
10
19
0
10
0
0
0
64
0
10
% G
% His:
0
0
0
10
0
64
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
28
28
0
10
0
10
0
0
10
0
0
0
0
0
% I
% Lys:
0
19
0
0
0
0
0
0
0
0
0
10
0
0
0
% K
% Leu:
0
0
19
37
64
19
0
0
0
0
0
0
0
91
0
% L
% Met:
0
0
46
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
19
% Q
% Arg:
0
19
0
19
0
0
0
0
0
0
82
19
0
0
0
% R
% Ser:
0
10
0
0
0
0
0
19
64
0
0
37
0
0
10
% S
% Thr:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
19
0
0
28
0
0
0
0
19
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
64
73
0
10
0
0
0
10
19
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _