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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
14.55
Human Site:
S108
Identified Species:
24.62
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
S108
D
S
D
G
E
G
E
S
D
D
P
E
K
K
K
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
S108
D
S
D
G
E
G
E
S
D
D
P
E
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
N182
D
S
D
S
E
G
D
N
P
E
K
K
K
L
Q
Dog
Lupus familis
XP_848812
444
49189
T108
D
S
D
G
E
G
E
T
D
D
P
E
K
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
S108
D
S
D
G
E
A
E
S
D
D
P
E
K
K
K
Rat
Rattus norvegicus
Q5XIK7
488
55183
R118
P
Q
I
R
R
P
N
R
E
V
R
P
L
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
N150
D
S
D
S
E
G
E
N
P
E
K
K
K
L
Q
Chicken
Gallus gallus
Q1HGK7
492
56020
V134
N
N
R
I
S
A
A
V
R
G
P
H
R
P
S
Frog
Xenopus laevis
Q9PUL2
486
55412
S125
V
Q
C
N
D
N
K
S
H
N
N
R
F
S
A
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
P118
V
Q
V
K
K
P
V
P
L
S
K
P
Q
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
K112
D
S
D
P
E
K
K
K
L
Q
S
K
L
E
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
R134
P
P
Y
Q
R
A
A
R
K
D
P
P
R
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
M118
T
S
S
G
G
G
P
M
D
D
P
D
V
W
R
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
N112
E
D
N
G
G
E
D
N
K
K
L
R
G
A
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
100
40
93.3
N.A.
93.3
6.6
N.A.
46.6
6.6
6.6
6.6
N.A.
N.A.
26.6
N.A.
13.3
P-Site Similarity:
100
100
73.3
100
N.A.
93.3
20
N.A.
73.3
26.6
26.6
26.6
N.A.
N.A.
46.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
22
15
0
0
0
0
0
0
8
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
8
50
0
8
0
15
0
36
43
0
8
0
0
0
% D
% Glu:
8
0
0
0
50
8
36
0
8
15
0
29
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
43
15
43
0
0
0
8
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% H
% Ile:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
8
15
8
15
8
22
22
43
29
43
% K
% Leu:
0
0
0
0
0
0
0
0
15
0
8
0
15
15
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
8
8
8
8
0
8
8
22
0
8
8
0
0
0
0
% N
% Pro:
15
8
0
8
0
15
8
8
15
0
50
22
0
8
0
% P
% Gln:
0
22
0
8
0
0
0
0
0
8
0
0
8
0
15
% Q
% Arg:
0
0
8
8
15
0
0
15
8
0
8
15
15
22
8
% R
% Ser:
0
58
8
15
8
0
0
29
0
8
8
0
0
8
15
% S
% Thr:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
15
0
8
0
0
0
8
8
0
8
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _