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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS4B All Species: 6.06
Human Site: S2 Identified Species: 10.26
UniProt: O75351 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75351 NP_004860.2 444 49302 S2 _ _ _ _ _ _ M S S T S P N L Q
Chimpanzee Pan troglodytes XP_001146376 412 45621 S2 _ _ _ _ _ _ M S S T S P N L Q
Rhesus Macaque Macaca mulatta XP_001093648 516 56751 E79 C G A D P G D E M T T S T L Q
Dog Lupus familis XP_848812 444 49189 A2 _ _ _ _ _ _ M A S T S A N F Q
Cat Felis silvestris
Mouse Mus musculus P46467 444 49401 A2 _ _ _ _ _ _ M A S T N T N L Q
Rat Rattus norvegicus Q5XIK7 488 55183 R14 C E N A K K G R E Y A L L G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510255 484 54482 E47 S W R V K W R E A L G G D L K
Chicken Gallus gallus Q1HGK7 492 56020 E8 M S L V M I S E N V K L A R E
Frog Xenopus laevis Q9PUL2 486 55412 L3 _ _ _ _ _ M S L L M I S E N V
Zebra Danio Brachydanio rerio Q5U3S1 488 54873 D8 M N L T E I C D N A K K G R E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393250 441 49311 Q8 M A S G T I L Q K A I D L V T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus O61577 516 57575 V3 _ _ _ _ _ M S V D E I C E N T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 V2 _ _ _ _ _ _ M V G S S N S L A
Baker's Yeast Sacchar. cerevisiae P52917 437 48154 T8 M S T G D F L T K G I E L V Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.7 70.1 96.4 N.A. 95.5 35.2 N.A. 74.1 36.3 36.4 36.4 N.A. N.A. 75.9 N.A. 34.8
Protein Similarity: 100 92.7 79 97.5 N.A. 97.3 54.9 N.A. 83.4 54.2 54.1 54.9 N.A. N.A. 87.8 N.A. 53.1
P-Site Identity: 100 100 20 66.6 N.A. 66.6 0 N.A. 6.6 0 0 0 N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 100 40 77.7 N.A. 88.8 6.6 N.A. 26.6 20 0 20 N.A. N.A. 26.6 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 35.5 61 N.A.
Protein Similarity: N.A. N.A. N.A. 54.1 74.5 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 55.5 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 0 0 0 15 8 15 8 8 8 0 8 % A
% Cys: 15 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 0 8 8 0 8 8 8 0 0 8 8 0 0 % D
% Glu: 0 8 0 0 8 0 0 22 8 8 0 8 15 0 15 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 8 0 15 0 8 8 0 8 8 8 8 8 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 22 0 0 0 0 29 0 0 0 0 % I
% Lys: 0 0 0 0 15 8 0 0 15 0 15 8 0 0 8 % K
% Leu: 0 0 15 0 0 0 15 8 8 8 0 15 22 43 0 % L
% Met: 29 0 0 0 8 15 36 0 8 8 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 0 15 0 8 8 29 15 8 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 0 15 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 43 % Q
% Arg: 0 0 8 0 0 0 8 8 0 0 0 0 0 15 0 % R
% Ser: 8 15 8 0 0 0 22 15 29 8 29 15 8 0 0 % S
% Thr: 0 0 8 8 8 0 0 8 0 36 8 8 8 0 15 % T
% Val: 0 0 0 15 0 0 0 15 0 8 0 0 0 15 8 % V
% Trp: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 50 50 50 50 50 36 0 0 0 0 0 0 0 0 0 % _