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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
26.36
Human Site:
S248
Identified Species:
44.62
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
S248
G
S
R
S
E
N
E
S
E
A
A
R
R
I
K
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
R224
K
N
L
F
Q
L
A
R
E
N
K
P
S
I
I
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
S320
G
S
R
N
E
N
E
S
E
A
A
R
R
I
K
Dog
Lupus familis
XP_848812
444
49189
S248
G
S
R
S
E
N
E
S
E
A
A
R
R
I
K
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
S248
G
S
R
S
E
N
E
S
E
A
A
R
R
I
K
Rat
Rattus norvegicus
Q5XIK7
488
55183
L275
F
N
V
S
S
S
T
L
T
S
K
Y
R
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
S288
G
S
R
N
E
N
E
S
E
A
A
R
R
I
K
Chicken
Gallus gallus
Q1HGK7
492
56020
L279
F
N
V
S
S
S
T
L
T
S
K
Y
R
G
E
Frog
Xenopus laevis
Q9PUL2
486
55412
L275
F
N
I
S
S
S
T
L
T
S
K
Y
R
G
E
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
L275
F
N
V
S
S
S
T
L
T
S
K
Y
R
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
S245
S
S
R
S
D
N
E
S
E
S
A
R
R
I
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
L303
F
N
V
S
S
A
S
L
T
S
K
Y
H
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
A242
G
V
R
W
D
D
V
A
G
L
S
E
A
K
R
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
S246
G
T
R
G
E
G
E
S
E
A
S
R
R
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
13.3
93.3
100
N.A.
100
13.3
N.A.
93.3
13.3
13.3
13.3
N.A.
N.A.
80
N.A.
6.6
P-Site Similarity:
100
26.6
100
100
N.A.
100
40
N.A.
100
40
40
40
N.A.
N.A.
93.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
73.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
8
0
43
43
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
15
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
43
0
50
0
58
0
0
8
0
0
36
% E
% Phe:
36
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
50
0
0
8
0
8
0
0
8
0
0
0
0
36
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
0
0
58
8
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
43
0
0
8
50
% K
% Leu:
0
0
8
0
0
8
0
36
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
43
0
15
0
43
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
58
0
0
0
0
8
0
0
0
50
79
0
8
% R
% Ser:
8
43
0
65
36
29
8
50
0
43
15
0
8
0
0
% S
% Thr:
0
8
0
0
0
0
29
0
36
0
0
0
0
0
0
% T
% Val:
0
8
29
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
36
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _