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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
32.12
Human Site:
S369
Identified Species:
54.36
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
S369
F
K
K
V
R
G
P
S
R
A
D
P
N
H
L
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
S337
G
R
K
T
D
G
Y
S
G
A
D
I
S
I
I
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
S441
F
K
K
V
C
G
P
S
R
T
N
P
S
V
M
Dog
Lupus familis
XP_848812
444
49189
S369
F
K
K
V
C
G
P
S
R
A
D
P
N
K
I
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
S369
F
K
K
V
R
G
P
S
R
A
D
P
N
C
I
Rat
Rattus norvegicus
Q5XIK7
488
55183
S414
A
E
K
T
E
G
Y
S
G
A
D
I
T
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
S409
F
K
K
V
R
G
P
S
R
T
N
P
G
I
I
Chicken
Gallus gallus
Q1HGK7
492
56020
S418
A
E
K
M
E
G
Y
S
G
A
D
I
T
N
V
Frog
Xenopus laevis
Q9PUL2
486
55412
N391
R
E
E
L
L
R
I
N
L
K
E
L
E
L
A
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
S414
A
E
K
I
E
G
Y
S
G
A
D
I
T
N
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
S366
F
K
R
V
R
G
P
S
P
K
D
P
S
I
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
S442
A
E
K
M
D
G
Y
S
G
A
D
I
T
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
G449
R
R
T
E
G
Y
S
G
D
D
L
T
N
V
C
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
K361
I
Q
S
A
T
H
F
K
D
V
S
T
E
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
33.3
60
80
N.A.
86.6
33.3
N.A.
66.6
33.3
0
33.3
N.A.
N.A.
60
N.A.
33.3
P-Site Similarity:
100
53.3
80
86.6
N.A.
93.3
53.3
N.A.
80
60
33.3
60
N.A.
N.A.
80
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
0
0
8
0
0
0
0
0
58
0
0
0
0
8
% A
% Cys:
0
0
0
0
15
0
0
0
0
0
0
0
0
8
8
% C
% Asp:
0
0
0
0
15
0
0
0
15
8
65
0
0
8
8
% D
% Glu:
0
36
8
8
22
0
0
0
0
0
8
0
15
0
0
% E
% Phe:
43
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
8
79
0
8
36
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
0
8
0
0
8
0
0
0
0
36
0
22
43
% I
% Lys:
0
43
72
0
0
0
0
8
0
15
0
0
0
8
0
% K
% Leu:
0
0
0
8
8
0
0
0
8
0
8
8
0
8
8
% L
% Met:
0
0
0
15
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
15
0
29
29
0
% N
% Pro:
0
0
0
0
0
0
43
0
8
0
0
43
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
15
8
0
29
8
0
0
36
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
8
79
0
0
8
0
22
0
0
% S
% Thr:
0
0
8
15
8
0
0
0
0
15
0
15
29
0
0
% T
% Val:
0
0
0
43
0
0
0
0
0
8
0
0
0
15
22
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
36
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _