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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS4B All Species: 25.45
Human Site: S385 Identified Species: 43.08
UniProt: O75351 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75351 NP_004860.2 444 49302 S385 D D L L T P C S P G D P G A I
Chimpanzee Pan troglodytes XP_001146376 412 45621 V353 R D A L M Q P V R K V Q S A T
Rhesus Macaque Macaca mulatta XP_001093648 516 56751 S457 D D L L T P C S P G D P G A M
Dog Lupus familis XP_848812 444 49189 S385 D D L L T P C S P G D P G A I
Cat Felis silvestris
Mouse Mus musculus P46467 444 49401 S385 N D L L T P C S P G D P G A I
Rat Rattus norvegicus Q5XIK7 488 55183 M430 R D A S L M A M R R R I N G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510255 484 54482 S425 D D L L T P C S P G D P E A I
Chicken Gallus gallus Q1HGK7 492 56020 M434 R D A S L M A M R R R I E G L
Frog Xenopus laevis Q9PUL2 486 55412 A407 D V N I E C I A E N M D G Y S
Zebra Danio Brachydanio rerio Q5U3S1 488 54873 M430 R D A S M M A M R R R I Q G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393250 441 49311 S382 D D L L T P C S P G D P A A I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus O61577 516 57575 M458 R D A S M M A M R R R I Q G L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 R465 D A S M N G M R R K I A G K T
Baker's Yeast Sacchar. cerevisiae P52917 437 48154 S377 T R K L T P C S P G D D G A I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.7 70.1 96.4 N.A. 95.5 35.2 N.A. 74.1 36.3 36.4 36.4 N.A. N.A. 75.9 N.A. 34.8
Protein Similarity: 100 92.7 79 97.5 N.A. 97.3 54.9 N.A. 83.4 54.2 54.1 54.9 N.A. N.A. 87.8 N.A. 53.1
P-Site Identity: 100 20 93.3 100 N.A. 93.3 6.6 N.A. 93.3 6.6 13.3 6.6 N.A. N.A. 93.3 N.A. 6.6
P-Site Similarity: 100 20 100 100 N.A. 100 13.3 N.A. 93.3 13.3 26.6 13.3 N.A. N.A. 93.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 35.5 61 N.A.
Protein Similarity: N.A. N.A. N.A. 54.1 74.5 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 73.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 36 0 0 0 29 8 0 0 0 8 8 58 0 % A
% Cys: 0 0 0 0 0 8 50 0 0 0 0 0 0 0 0 % C
% Asp: 50 79 0 0 0 0 0 0 0 0 50 15 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 8 0 0 0 15 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 0 0 50 0 0 50 29 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 8 0 0 0 8 29 0 0 43 % I
% Lys: 0 0 8 0 0 0 0 0 0 15 0 0 0 8 0 % K
% Leu: 0 0 43 58 15 0 0 0 0 0 0 0 0 0 29 % L
% Met: 0 0 0 8 22 29 8 29 0 0 8 0 0 0 8 % M
% Asn: 8 0 8 0 8 0 0 0 0 8 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 50 8 0 50 0 0 43 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 8 15 0 0 % Q
% Arg: 36 8 0 0 0 0 0 8 43 29 29 0 0 0 0 % R
% Ser: 0 0 8 29 0 0 0 50 0 0 0 0 8 0 8 % S
% Thr: 8 0 0 0 50 0 0 0 0 0 0 0 0 0 15 % T
% Val: 0 8 0 0 0 0 0 8 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _