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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
8.79
Human Site:
S419
Identified Species:
14.87
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
S419
S
D
M
L
R
S
L
S
N
T
K
P
T
V
N
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
G387
L
L
T
P
C
S
P
G
D
P
G
A
I
E
M
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
A491
S
D
M
L
R
S
L
A
T
T
R
P
T
V
N
Dog
Lupus familis
XP_848812
444
49189
S419
S
D
M
L
R
S
L
S
N
T
K
P
T
V
N
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
S419
W
D
M
L
R
S
L
S
S
T
K
P
T
V
N
Rat
Rattus norvegicus
Q5XIK7
488
55183
K464
G
D
L
E
L
A
L
K
K
I
A
K
S
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
V459
T
D
M
L
R
S
L
V
T
T
R
P
T
V
N
Chicken
Gallus gallus
Q1HGK7
492
56020
K468
E
D
F
E
I
A
L
K
K
V
S
K
S
V
S
Frog
Xenopus laevis
Q9PUL2
486
55412
E441
I
E
G
L
T
P
E
E
I
R
N
L
S
R
D
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
K464
E
D
F
E
L
A
L
K
K
I
S
K
S
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
A416
K
D
M
L
K
S
L
A
T
T
R
P
T
V
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
Q492
A
D
F
L
L
A
L
Q
K
V
S
K
S
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
R499
C
D
F
E
E
A
I
R
K
V
Q
P
S
V
S
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
K411
K
D
F
L
K
A
I
K
S
T
R
P
T
V
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
6.6
80
100
N.A.
86.6
20
N.A.
73.3
20
6.6
20
N.A.
N.A.
66.6
N.A.
26.6
P-Site Similarity:
100
13.3
93.3
100
N.A.
93.3
46.6
N.A.
86.6
40
26.6
40
N.A.
N.A.
86.6
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
43
0
15
0
0
8
8
0
0
0
% A
% Cys:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
86
0
0
0
0
0
0
8
0
0
0
0
0
8
% D
% Glu:
15
8
0
29
8
0
8
8
0
0
0
0
0
8
0
% E
% Phe:
0
0
36
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
0
0
0
0
8
0
0
8
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
15
0
8
15
0
0
8
0
0
% I
% Lys:
15
0
0
0
15
0
0
29
36
0
22
29
0
0
0
% K
% Leu:
8
8
8
65
22
0
72
0
0
0
0
8
0
0
0
% L
% Met:
0
0
43
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
15
0
8
0
0
0
50
% N
% Pro:
0
0
0
8
0
8
8
0
0
8
0
58
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
36
0
0
8
0
8
29
0
0
8
0
% R
% Ser:
22
0
0
0
0
50
0
22
15
0
22
0
43
0
29
% S
% Thr:
8
0
8
0
8
0
0
0
22
50
0
0
50
0
0
% T
% Val:
0
0
0
0
0
0
0
8
0
22
0
0
0
86
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _