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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
20.3
Human Site:
Y297
Identified Species:
34.36
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
Y297
R
R
F
E
K
R
I
Y
I
P
L
P
E
P
H
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
V267
V
Q
M
Q
G
V
G
V
D
N
D
G
I
L
V
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
Y369
R
R
F
E
K
R
I
Y
I
P
L
P
E
E
A
Dog
Lupus familis
XP_848812
444
49189
Y297
R
R
F
E
K
R
I
Y
I
P
L
P
E
A
H
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
Y297
R
R
F
E
K
R
I
Y
I
P
L
P
E
A
H
Rat
Rattus norvegicus
Q5XIK7
488
55183
K327
H
E
A
S
R
R
V
K
S
E
L
L
I
Q
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
Y337
R
R
F
E
K
R
I
Y
I
P
L
P
E
E
A
Chicken
Gallus gallus
Q1HGK7
492
56020
K331
H
E
A
S
R
R
V
K
A
E
L
L
V
Q
M
Frog
Xenopus laevis
Q9PUL2
486
55412
H320
R
R
G
T
S
E
E
H
E
A
S
R
R
V
K
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
Q333
V
K
S
E
L
L
V
Q
M
D
G
V
G
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
Y294
R
R
F
E
K
R
I
Y
I
P
L
P
D
E
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
H348
K
R
G
T
G
S
E
H
E
A
S
R
R
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
V320
R
G
E
S
E
R
M
V
R
C
L
F
D
L
A
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
F290
D
S
A
I
R
R
R
F
E
R
R
I
Y
I
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
0
86.6
93.3
N.A.
93.3
13.3
N.A.
86.6
13.3
13.3
6.6
N.A.
N.A.
80
N.A.
6.6
P-Site Similarity:
100
13.3
86.6
93.3
N.A.
93.3
26.6
N.A.
86.6
26.6
20
26.6
N.A.
N.A.
86.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
22
0
0
0
0
0
8
15
0
0
0
15
29
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
8
8
8
0
15
0
0
% D
% Glu:
0
15
8
50
8
8
15
0
22
15
0
0
36
22
0
% E
% Phe:
0
0
43
0
0
0
0
8
0
0
0
8
0
0
0
% F
% Gly:
0
8
15
0
15
0
8
0
0
0
8
8
8
8
0
% G
% His:
15
0
0
0
0
0
0
15
0
0
0
0
0
0
22
% H
% Ile:
0
0
0
8
0
0
43
0
43
0
0
8
15
8
0
% I
% Lys:
8
8
0
0
43
0
0
15
0
0
0
0
0
0
15
% K
% Leu:
0
0
0
0
8
8
0
0
0
0
65
15
0
15
0
% L
% Met:
0
0
8
0
0
0
8
0
8
0
0
0
0
0
15
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
43
0
43
0
8
8
% P
% Gln:
0
8
0
8
0
0
0
8
0
0
0
0
0
15
8
% Q
% Arg:
58
58
0
0
22
72
8
0
8
8
8
15
15
0
0
% R
% Ser:
0
8
8
22
8
8
0
0
8
0
15
0
0
0
0
% S
% Thr:
0
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
15
0
0
0
0
8
22
15
0
0
0
8
8
15
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
43
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _